ID A7ATY9_BABBO Unreviewed; 525 AA.
AC A7ATY9;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Leucine aminopeptidase, putative {ECO:0000313|EMBL:EDO06400.1};
GN ORFNames=BBOV_II004450 {ECO:0000313|EMBL:EDO06400.1};
OS Babesia bovis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5865 {ECO:0000313|EMBL:EDO06400.1, ECO:0000313|Proteomes:UP000002173};
RN [1] {ECO:0000313|EMBL:EDO06400.1, ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T2Bo {ECO:0000313|EMBL:EDO06400.1};
RX PubMed=17953480; DOI=10.1371/journal.ppat.0030148;
RA Brayton K.A., Lau A.O.T., Herndon D.R., Hannick L., Kappmeyer L.S.,
RA Berens S.J., Bidwell S.L., Brown W.C., Crabtree J., Fadrosh D.,
RA Feldblum T., Forberger H.A., Haas B.J., Howell J.M., Khouri H., Koo H.,
RA Mann D.J., Norimine J., Paulsen I.T., Radune D., Ren Q., Smith R.K. Jr.,
RA Suarez C.E., White O., Wortman J.R., Knowles D.P. Jr., McElwain T.F.,
RA Nene V.M.;
RT "Genome sequence of Babesia bovis and comparative analysis of apicomplexan
RT hemoprotozoa.";
RL PLoS Pathog. 3:1401-1413(2007).
RN [2] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33294524; DOI=10.1016/j.dib.2020.106533;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Transcriptome dataset of Babesia bovis life stages within vertebrate and
RT invertebrate hosts.";
RL Data Brief 33:106533-106533(2020).
RN [3] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33069745;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Comparative analysis of gene expression between Babesia bovis blood stages
RT and kinetes allowed by improved genome annotation.";
RL Int. J. Parasitol. 51:123-136(2021).
CC -!- SIMILARITY: Belongs to the peptidase M17 family.
CC {ECO:0000256|ARBA:ARBA00009528}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO06400.1}.
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DR EMBL; AAXT01000003; EDO06400.1; -; Genomic_DNA.
DR RefSeq; XP_001609968.1; XM_001609918.1.
DR AlphaFoldDB; A7ATY9; -.
DR STRING; 5865.A7ATY9; -.
DR EnsemblProtists; EDO06400; EDO06400; BBOV_II004450.
DR GeneID; 5478197; -.
DR KEGG; bbo:BBOV_II004450; -.
DR VEuPathDB; PiroplasmaDB:BBOV_II004450; -.
DR eggNOG; KOG2597; Eukaryota.
DR InParanoid; A7ATY9; -.
DR OMA; LFYEYVT; -.
DR Proteomes; UP000002173; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00433; Peptidase_M17; 1.
DR Gene3D; 3.40.220.10; Leucine Aminopeptidase, subunit E, domain 1; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR011356; Leucine_aapep/pepB.
DR InterPro; IPR043472; Macro_dom-like.
DR InterPro; IPR000819; Peptidase_M17_C.
DR PANTHER; PTHR11963; LEUCINE AMINOPEPTIDASE-RELATED; 1.
DR PANTHER; PTHR11963:SF23; ZGC:152830; 1.
DR Pfam; PF00883; Peptidase_M17; 1.
DR PRINTS; PR00481; LAMNOPPTDASE.
DR SUPFAM; SSF52949; Macro domain-like; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00631; CYTOSOL_AP; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW ECO:0000313|EMBL:EDO06400.1}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000002173}.
FT DOMAIN 376..383
FT /note="Cytosol aminopeptidase"
FT /evidence="ECO:0000259|PROSITE:PS00631"
SQ SEQUENCE 525 AA; 56606 MW; 99F5EC8E9282A567 CRC64;
MEKILEFPST DSPVNGVEIS LLQTSDAPGS DVIKGYQGGV AIFHLCFTAT TPSTDKKPGF
DQSKFDVFPT GFITNSDGVK AVIGYSGFSG KCGDLVEYFD RCDDGSLLSE AVVGCGPHKE
FCASDAYTVS KTIAKAISTH QCKHAIFMVG GLEPVLIESL VIGSLNCISV DRRFKKDTNV
EYYLESLHVI ADAISELNTF QTRCKAFVRG MHTTRELVTA PANYANTESI AGFLQNRLTG
LGLEVRIIEE DECRALGMGA YLAVGQGSQY PPKFLHAIYR SSVSVKTKIA LVGKGIMFDT
GGLNIKSAAS EIELMKFDMG GMSTVFGAAE TIAALKPHGV EVHFISATCE NMAGSNAYRP
GDIVTASNGK TIEVINTDAE GRLTLADALV YADKLGVDYI VDLATLTGAC IIALGYQYGG
YFVNDESFHQ RFQKALSDSG ELAWRLPLAR EYKEGLESKV ADLSNCNYTA KAGTVMAALF
LNEFVENAKW IHWDIAGTAF DKSTGRGTAY GLRTIVNLVL DMAEE
//
