ID A7EE51_SCLS1 Unreviewed; 2215 AA.
AC A7EE51;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDO01117.1};
GN ORFNames=SS1G_03591 {ECO:0000313|EMBL:EDO01117.1};
OS Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)
OS (Whetzelinia sclerotiorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Sclerotinia.
OX NCBI_TaxID=665079 {ECO:0000313|EMBL:EDO01117.1, ECO:0000313|Proteomes:UP000001312};
RN [1] {ECO:0000313|Proteomes:UP000001312}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18683 / 1980 / Ss-1 {ECO:0000313|Proteomes:UP000001312};
RX PubMed=21876677; DOI=.1371/journal.pgen.1002230;
RA Amselem J., Cuomo C.A., van Kan J.A., Viaud M., Benito E.P., Couloux A.,
RA Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.M.,
RA Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA Grossetete S., Guldener U., Henrissat B., Howlett B.J., Kodira C.,
RA Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA Zeng Q., Rollins J.A., Lebrun M.H., Dickman M.;
RT "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT sclerotiorum and Botrytis cinerea.";
RL PLoS Genet. 7:E1002230-E1002230(2011).
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DR EMBL; CH476624; EDO01117.1; -; Genomic_DNA.
DR RefSeq; XP_001595502.1; XM_001595452.1.
DR STRING; 665079.A7EE51; -.
DR EnsemblFungi; EDO01117; EDO01117; SS1G_03591.
DR GeneID; 5492047; -.
DR KEGG; ssl:SS1G_03591; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_31_0_1; -.
DR InParanoid; A7EE51; -.
DR OMA; YSAACAY; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000001312; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0004312; F:fatty acid synthase activity; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IBA:GO_Central.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001312};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..385
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2126..2203
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2215 AA; 245026 MW; A2019304520027CF CRC64;
MGESSTKIEP LAIVGLSFKF PQGMETANSL WKGLASSRSA WSSFPESRLN FDGVYDPDTG
RLNSFPLKGA HFLNGDISAF DAPFFTIGPS EAAEIDPQSR ILLEVTYRAL ENANRISWYF
NLRGESINMD TACSSTLVAF HTACERLRSR ESNMAIVAGS NLFLSPDMAM SLNNQNFLSP
DGRCWSFDEK ANGYGRGEGF GVLVVKRLSD ALENNDPIRA AVLATGTNQD GRTPGIVQPS
RSAQAQLIRD VYRKAGLDMS QTRYVEAHGT GTSVGDPIEA GAIADAFSHT LSADSPLFIG
SIKSNIGHLE GTSGIAGLVK SVLILERRMI PGIAGLEHVN HSIVAEHPHL KFPKDLTSWP
SDSLCRLSIN SFGFGGTNAH VIMEDAAGYL DNREKAINRT QVNGTNHANH DQRPMTNGFH
HLETRRILVF SAQDENGIKR LESAYNDHWS QMNKDELSDS YMSRLSYTLG NRRSALLWRS
FATVNSKNDL ITGIKFSRAV RALPRARLAF CFTGQGAQWY AMGRDIQAPI FKQSLRELSE
LLTDMGCLWS LQAELSRDKE TSRINRPEFS QPICTAIQIA LIDLLEGLDI KPSVAFGHSS
GEIATAYCVG ALDKRSAMSV AYYRGLLSSK VAEDKMIQGG MLSAGLSAKE VLPYLARVEA
KFGYSGVVVG CINSPNNVTI TGDIEQINYL NELLEKESIF SRKLLVDVAY HSHHMNAIAA
AYSEKLGNLS SRNSAKLIPM VSSVTGEVVS SDKLRQPGYW VENMVSPVRF LDAISCAPSL
RVSEDGSISY NDSKDFFDDV LEIGPHSALQ GPIKDFLKLY GTPVPDWNPQ EAKWRRRIKL
SEDPWIEDHK IANACILPAS AMLVMAIEAA KIMAKLRSNK AISGFIVQNV VVSRALTIPS
DPDGTEIEFY LRPCGLASDR EITWSNFRIY IPENDNWVEV CRGQVRATHF EVGDEVDNGL
EDSLSDEYHR AELWRIRGSS CQKVDMERFY PTLRENGIDF GTAHQTIKNG SYGQNMECVG
DIALDSWVSK KREFQQMDFT IHPTSLDGLF QLGLLALVGE TSKINPSVIV GLRKLWVSEG
KINVAGSSIM PTYAKSAMNG ATGTLINTVA FENQALNPVI ILDGLEGKFL EQTKKSTEKQ
NYHLSWNFDY RPDIELLSKE ELIHAVNVKE YLNDDMFYEK LLSRLEHSNA RGKLYAVLSK
NLRNILMGKV DALELMFKEP LVKDYYRELY KSTNGLSKTL AYLDILTHKH PNMNILEIGA
GTGGMTNYLL DVLAQNGARD PRVGTPRFSH YTYTDISAGF FEGAAPLFQN FSDMVTFKVL
DIEKDPAHQG FEAGGYDCII ADNVLHATRD LDVTIKNVRK LLKPGGKLML FELTVPEVVR
TNFAFGLLPG WWRFNDKYRS FSAGISDSVW DRVLKSSGFS GIDFNFKDYE EDECHEHSAL
VSTARGDTLS ISPFLLTVVV LDPQSDLQRK IYELLRHTLQ SAGTENILSM TLKEAATFHG
NSAFGIVLLE LDRPLLQEMT EPNFKDVKAM FLAFENILWA CKGGGERPDL PEYALVQGAF
RALRMENIRL KFISLSFEAT STNPTHLANK VFEVYQKVST TAVKDCEQEY VERNGMICID
RIIDADYMNQ KLSETAEDKP RSDCEFCSAP PVALSIKTPG LLDTLEFVED SAARTNLASD
EIEIEVEASG VNFRDCLIAL GRIPSMSFGF ECSGTIHRIG SHATKLKLGD RVCASTLGTY
QTYARCNASN VIPIPSYMSF IDAAALPVVF TTAYYAIVHV AQLRKGESIL IHSAAGGTGQ
AAIQIAKLLG AEIFVTVGSK SKKDLLISLY QIPEDHIFYS RNAFFVKGIQ RMTGDHGGVD
VVLNSLSGDL LVDTWQCIAP FGRFLEIGKK DILANGNLPM LPFSRNASFH AIDLNEARKY
RPGLLLDLKN SITTLLFDDK IRPPQPVHVY GISEVEKAFR YLQSGKNSGK TVIEFRGPDI
IKSSVFENMT YEDWVGANKC KVSGTWNLHT LLPKGLDHFI VYSSISGAIG GTASVNYSAA
CAYQDALVHY RNKVGEKATT FNLGVMVDDG VLRDNTAARR AEVPAMMTRP MFRGTWSINE
QGKTGAKEDV ATDVTSQLHG VASETEAANI IANALMQRLS NALAVPMKNL DSSRPMHIYG
VDSLIAVELR NWFNQKLDAD IAVFEILGEV TFRDIGFLVA GKSKLVEAIL KKVVK
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