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Database: UniProt
Entry: A7ESL8
LinkDB: A7ESL8
Original site: A7ESL8 
ID   DBP4_SCLS1              Reviewed;         808 AA.
AC   A7ESL8;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   16-OCT-2019, entry version 70.
DE   RecName: Full=ATP-dependent RNA helicase dbp4;
DE            EC=3.6.4.13;
GN   Name=dbp4; ORFNames=SS1G_08323;
OS   Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White
OS   mold) (Whetzelinia sclerotiorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Sclerotiniaceae; Sclerotinia.
OX   NCBI_TaxID=665079;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18683 / 1980 / Ss-1;
RX   PubMed=21876677; DOI=10.1371/journal.pgen.1002230;
RA   Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P.,
RA   Couloux A., Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S.,
RA   Fournier E., Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M.,
RA   Pradier J.-M., Quevillon E., Sharon A., Simon A., ten Have A.,
RA   Tudzynski B., Tudzynski P., Wincker P., Andrew M., Anthouard V.,
RA   Beever R.E., Beffa R., Benoit I., Bouzid O., Brault B., Chen Z.,
RA   Choquer M., Collemare J., Cotton P., Danchin E.G., Da Silva C.,
RA   Gautier A., Giraud C., Giraud T., Gonzalez C., Grossetete S.,
RA   Gueldener U., Henrissat B., Howlett B.J., Kodira C., Kretschmer M.,
RA   Lappartient A., Leroch M., Levis C., Mauceli E., Neuveglise C.,
RA   Oeser B., Pearson M., Poulain J., Poussereau N., Quesneville H.,
RA   Rascle C., Schumacher J., Segurens B., Sexton A., Silva E., Sirven C.,
RA   Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA   Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.;
RT   "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT   sclerotiorum and Botrytis cinerea.";
RL   PLoS Genet. 7:E1002230-E1002230(2011).
CC   -!- FUNCTION: ATP-dependent RNA helicase required for ribosome
CC       biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal
CC       complexes. Required for pre-rRNA cleavage at site A2 (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Interacts with the U3 and U14 snoRNAs. Associates with
CC       pre-ribosomal complexes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX10/DBP4
CC       subfamily. {ECO:0000305}.
DR   EMBL; CH476631; EDN92460.1; -; Genomic_DNA.
DR   RefSeq; XP_001590583.1; XM_001590533.1.
DR   SMR; A7ESL8; -.
DR   STRING; 5180.EDN92460; -.
DR   EnsemblFungi; EDN92460; EDN92460; SS1G_08323.
DR   GeneID; 5486703; -.
DR   KEGG; ssl:SS1G_08323; -.
DR   EuPathDB; FungiDB:SS1G_08323; -.
DR   InParanoid; A7ESL8; -.
DR   KO; K14776; -.
DR   OMA; KVRTKYD; -.
DR   Proteomes; UP000001312; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR025313; DUF4217.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF13959; DUF4217; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01178; DUF4217; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    808       ATP-dependent RNA helicase dbp4.
FT                                /FTId=PRO_0000310200.
FT   DOMAIN       80    254       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      280    439       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND      93    100       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF        49     77       Q motif.
FT   MOTIF       202    205       DEAD box.
FT   COMPBIAS    555    604       Asp-rich.
SQ   SEQUENCE   808 AA;  90928 MW;  11FA4E3B74AF33E1 CRC64;
     MAPPSVGRKS KNISKGKVDA RTLKRKRVEE DLEKLQKSVD ELDAKAEIKN FSELPLSGPT
     SSGLEASHFK TLTDVQSKAV PLALKGKDIL GAAKTGSGKT LAFLVPVLEN LYRQKWTELD
     GLGALIISPT RELAIQIFEV LRKIGRYHTF SAGLIIGGRS LQEERERLGR MNILVCTPGR
     MLQHMDQTAA FDVDNLQMLV LDEADRIMDM GFQTSVDAIL EHLPKQRQTM LFSATQTKKV
     SDLARLSLKE PEYVAVHEAA SSATPTTLQQ HYCVVPLPEK LNTLFGFIRA NLKAKIIVFM
     SSGKQVRFVY ESLRHLQPGI PLLHLHGRQK QTARLDITSK FSSSKNSCIF ATDVVARGLD
     FPAVDWVIQL DCPEDADTYI HRVGRTARYG KVGRAVLFLD PSEEEGMLKR LEHKKVPIQK
     INIRPNKTQD IKNQLQNMCF QDPELKYLGQ KAFVSYAKSV FLQKDKEIFN INDIDLEGYA
     SSIGLPGAPK IKFQKGNDAK NVKNAPRAAI ESSDEDSETE KKPKKKDEVR TKYDRMFERR
     NQDVLSGHYS KMIADDTPMK DVDGTADADE DNDFLSVKRV LPVDNDDTSD DEDDDDDDDD
     DDDDVAATGP LGKVIEGISK DPIVIDSKRK EKLLKSKKKL LKLKDRGTKL VFDEEGNPHQ
     VYELQDEEDF RAKGTAEEQR AKFLEEEAER VREADLLDKQ TAKDKKREKR EKRKAREAAL
     DDDDEEALEL VDAGDDEDPM ALLKSLPLPE DEEDEDSTAR PAKRPKKWFE DDSDDERKVA
     KRKGRVIEAA DEPETLEDLE ALAAGLLN
//
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