ID A7EWH1_SCLS1 Unreviewed; 675 AA.
AC A7EWH1;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 03-MAY-2023, entry version 62.
DE RecName: Full=Nucleolar complex-associated protein 3 {ECO:0000256|PIRNR:PIRNR028977};
GN ORFNames=SS1G_09680 {ECO:0000313|EMBL:EDN93813.1};
OS Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)
OS (Whetzelinia sclerotiorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Sclerotinia.
OX NCBI_TaxID=665079 {ECO:0000313|EMBL:EDN93813.1, ECO:0000313|Proteomes:UP000001312};
RN [1] {ECO:0000313|Proteomes:UP000001312}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18683 / 1980 / Ss-1 {ECO:0000313|Proteomes:UP000001312};
RX PubMed=21876677; DOI=.1371/journal.pgen.1002230;
RA Amselem J., Cuomo C.A., van Kan J.A., Viaud M., Benito E.P., Couloux A.,
RA Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.M.,
RA Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA Grossetete S., Guldener U., Henrissat B., Howlett B.J., Kodira C.,
RA Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA Zeng Q., Rollins J.A., Lebrun M.H., Dickman M.;
RT "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT sclerotiorum and Botrytis cinerea.";
RL PLoS Genet. 7:E1002230-E1002230(2011).
CC -!- FUNCTION: Required for synthesis of 60S ribosomal subunits and the
CC transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
CC {ECO:0000256|PIRNR:PIRNR028977}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|PIRNR:PIRNR028977}.
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family.
CC {ECO:0000256|ARBA:ARBA00007797, ECO:0000256|PIRNR:PIRNR028977}.
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DR EMBL; CH476634; EDN93813.1; -; Genomic_DNA.
DR RefSeq; XP_001589047.1; XM_001588997.1.
DR AlphaFoldDB; A7EWH1; -.
DR STRING; 665079.A7EWH1; -.
DR GeneID; 5485515; -.
DR KEGG; ssl:SS1G_09680; -.
DR VEuPathDB; FungiDB:sscle_01g000570; -.
DR InParanoid; A7EWH1; -.
DR OMA; HYCPQVR; -.
DR OrthoDB; 24935at2759; -.
DR Proteomes; UP000001312; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR011501; Noc3_N.
DR InterPro; IPR016903; Nucleolar_cplx-assoc_3.
DR PANTHER; PTHR14428; NUCLEOLAR COMPLEX PROTEIN 3; 1.
DR PANTHER; PTHR14428:SF5; NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF07540; NOC3p; 1.
DR PIRSF; PIRSF028977; Nucleolar_complex_p3; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001312};
KW Ribosome biogenesis {ECO:0000256|PIRNR:PIRNR028977}.
FT DOMAIN 123..214
FT /note="Nucleolar complex-associated protein 3 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07540"
FT DOMAIN 477..662
FT /note="CCAAT-binding factor"
FT /evidence="ECO:0000259|Pfam:PF03914"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 675 AA; 75480 MW; 7AE96C6EDE3B4226 CRC64;
MAKVPAVKRR KLTPPPTEGE DSSPSTLENA PSSNAFFKTA SKWNLEQDYE TRPRKGKKEK
KESTRLPIKT KEGLIQQVEA PVEVNEEESD LEWIGADDVE EDEEPEEKVE EKPSVPIRQQ
IMEAKEELAR IALMLNEDPE ENVGAFRAIA EFGKSQNLTI KKLALATQLA VYKDVIPGYR
IRPLSEENME EKVSKEVRKL RAYEQALVGG YQGYVKELAR LVTSGRPQNK SDGGASLSTV
AISCACALLE AVPHFNFRSD LLKILVGKLS TRQVDNEFVK CRETIETLFK NDDDGTSSLD
AVNILTRMMK GRGYRVDESV LNTFLHLRLL SEFSGKASTN HVEHEEDSFG GKKLKEKRVF
RTKKERKLMK ERKAVEKEMI QADATVSHED RERMQSETLK LVFVTYFRIL KVRSPSLMGA
VLEGLARYAH LINQDFFGDL LEALKDLIGH AETGDDVEET EAEDEDSESS RNLTRESLLC
IITAFALLEG QDAHKAQASL SLDLSFFITH LYRTLHALSL NPDIELCSKS LHLPDPNAPS
TSNNKVNIQT TTVLLLKSLS SVLLPPLAAR AVPPLRIAAF TKQLMTCSLQ LPEKSATAMM
ALLGKVAKIH ETKVKSLWNT EERKGDGMFD GCSAEVEGSN PMASTIWEGE LLRLHYCPAV
REGVKVVEKN VIGLR
//
