ID A7F1D4_SCLS1 Unreviewed; 2524 AA.
AC A7F1D4;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDN95526.1};
GN ORFNames=SS1G_11404 {ECO:0000313|EMBL:EDN95526.1};
OS Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)
OS (Whetzelinia sclerotiorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Sclerotinia.
OX NCBI_TaxID=665079 {ECO:0000313|EMBL:EDN95526.1, ECO:0000313|Proteomes:UP000001312};
RN [1] {ECO:0000313|Proteomes:UP000001312}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18683 / 1980 / Ss-1 {ECO:0000313|Proteomes:UP000001312};
RX PubMed=21876677; DOI=.1371/journal.pgen.1002230;
RA Amselem J., Cuomo C.A., van Kan J.A., Viaud M., Benito E.P., Couloux A.,
RA Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.M.,
RA Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA Grossetete S., Guldener U., Henrissat B., Howlett B.J., Kodira C.,
RA Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA Zeng Q., Rollins J.A., Lebrun M.H., Dickman M.;
RT "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT sclerotiorum and Botrytis cinerea.";
RL PLoS Genet. 7:E1002230-E1002230(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH476638; EDN95526.1; -; Genomic_DNA.
DR RefSeq; XP_001587412.1; XM_001587362.1.
DR GeneID; 5483727; -.
DR KEGG; ssl:SS1G_11404; -.
DR InParanoid; A7F1D4; -.
DR OMA; VHTGCFT; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000001312; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0004312; F:fatty acid synthase activity; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IBA:GO_Central.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd05274; KR_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001312};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 26..450
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2434..2508
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 466..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2524 AA; 278201 MW; 204521649837EB7A CRC64;
MPQSLTVEEA NSFIPMTPDE SQEDQLEAIA VVGFGLNFPQ DADTPENFWK MLVDGRSAMT
DVPKDRWNID SFYHPSADRH DSMNARGGHF LKEDISLFDA PFFSMPPAEA VCMDPQQRSL
LECTYHALEN AGMPMASIIG SRTSCYVGSF SREYEAMINR DPQMQAKYVA VGTGTAMLAN
RLSWFYDLRG SSISLDTACS SSLVALHLAV DNLRSGESNM SIVAGCNLML NPDTNSIPLS
NLGFLGRDSV CYSFDHRANG YARGEGTAVM VLKPIKQALK DNDIIRAVIR NTGTNQDGRT
PGITQPSKEA QASLIQETYH RAGLDFKDTG FFEAHGTGTP IGDPREAGAI GIAFKDHVDE
PLVVGAVKSN IGHLEGASGL AGLIKTILIL EKGVIPRNIW FEKLNPEILA DEWKLKFPTD
TMAWPKEGLR RASVNSFGYG GANAHVIVDD AYHYLKSRKL AGKHQTVSSP PKVIHTNGMS
NGTTNGRTYG TTNGTNNGTE IQTTDPEKYR LFVWSASDEG GLRRLSTSYQ KYFQTLHSEK
ADFLDNLAYT LSRRRSNLPW KSFLVAISIE NIHHELSAGS LSKPVRSSAS LQPNLVFVFT
GQGAQWYAMG RELMIYPTFQ KVLSHAEKYL TTSLGCAWKL TEELKRSKDS SNVDNPALAQ
PLCTVIQIAL VELLEEWNIS PHAVVGHSSG EIAAAYCAGG ISKESAYKIA YHRGALANRL
AQKKRRNGAM IAVALSEAEI VSYLDQVAAQ LGPKRLVVGC VNSPKNITLT GDEECVDLMK
SLMNTQRIFA RKLQVPVAYH SSHMQEIASE YLKCIRGIVP REVSLTTKAF PTMFSSVTGA
LATSDRLSQP DYWVENMVSQ VKFAPALSEL CATLLRVQPE QTEIAPLCLV EVGPHAALQR
AVNETILADD TLSEASYDTT LRNGVNAIRS MMDLVGKLHC RGYKSDILAL NCPQRVEADL
KPLCDLPEYP FNHSQGYWLE SRISENYRFS EFPRHELLGV RTTDWNPLEA KWRNMIRVSE
LPWIKDHKFN GSELYPAAGM LVMAIEASRQ TARPNSKIAS YNIENVSFFK ALLVSLDAEG
VETQFHLRPA KDNTNSSDRK HFNLYLCSSG QWAEICCGTI VTEYEEVNDA EILGPRNDDH
LHSIWKNGVA RCTRLLDSKD LYENLASFGF GFGPTFQALK QVRWNNECEA TACLEPREWM
KKVKDSHITL DHVIHPTALD AVMHLTAAAE SKGTSNPLRT MVPTKIEKLW ISNDLLLHAE
NQTIQIFTHP TFQGYRDTEF SVVAFDNLAH ECQIVLEGYR ATAITSLEPS SAGDARLAFD
IDWKPAVDLL TDEECSTVCC ATVNKDDFHD PIFIDKAELL CTFYIYHALE ELNRRAYSGE
SHHTSKYIEW MRKQVDDYTS ANPIPNPEEN KPSLSDEEYF QMLSSELESG AEVDLINEVG
KNLARILIGD VDALGILFND DLAKGFYGGL TFVPSNKKAS TYIDLLAHKD PTLKILEIGA
GTGGSTASIL DKLGKHGNDE KGEPRLGKYT YTDISPGFFE AASQRFSDFV DVMEFKVLDI
EKDPIEQGLN VGEYDVVVAS AVLHATANLE NTLGNVHKML KPNGTLLIIE PCNLEALRIP
FIFGLLPGWW LSTEEHRFWG PLMSDDTWSS ELKNAGFTGA DICLRDFEDH RHTMSVIISK
PAGDKISNIL PPIPKTVIVV AERYKKETPL VAYLRSALIF HGISTDVIGC NEITSADLKD
SVCISLLEID NPFLCNITDD EWERLKTIVR SANGVLWLTR GAENDPALGM ITGLARGLRS
EYPHLNFVEV ALEENCTTET IVKHSLNVLR KSINSDPIER NENEYWEKDR ILYVNRVVEA
NYLNTHLTAR TATQKPQQRV LGSKPDTQIS LAIHNPGLLN TLRFEEGEVG RKELSPDQIE
VHVKAAGLTF KDVQIALGQI PGNYLGLEFS GIVVRVGSDV PEETLKSGDR ICGVAAGAFS
TKLHVPISQV FKIPDSISFT TAAAIPVSFC IARHSLVNLA KLKKGESILI HSAAGGVGQA
AIQLARTAEA VIYCTVGSQE KKELLCTKGL ISAASPLKIY GSSEVENAFR FLQSGKSTGK
TVVEMRSDDI ITAVPSSQPT YSFREDSSYV IIGGLGGLGK STATWMADRG AKHLILLGRS
GATSQAALEF VAEMELKGIA IAAPPCDVTD EVALLAVLDM CSKTMPPIKG CIQGSMVLRD
GLFESMSYEN YQDSVRPKVQ GSWNLHKHLP DSLDFFILLA SAGGIVGTRG QSNYASGNTY
QDALARYRVS RGLKCVSLDL GLIQGVGFAA ENRDTLLAIK KLGYRGIHEK EYLAILDYLC
DPSLPMMEDP LKSQIITGLE IPKVLLDTAE EAHDAEDWAR WVRRPLFRNL AAMEGLDASK
SDTGSVSESK KRLSEVDYKA AFAAAGTSAA AAARVASSGL REKLARTLRI PEEDIETQRS
IHTYGVDSLV AVDLRYWLAK EMKADLSIFE IMGDDSLGKL SWLIAKRTTL FAGEISDAQK
DQPA
//
