ID A7F2A6_SCLS1 Unreviewed; 1803 AA.
AC A7F2A6;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=SS1G_12053 {ECO:0000313|EMBL:EDN95848.1};
OS Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)
OS (Whetzelinia sclerotiorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Sclerotinia.
OX NCBI_TaxID=665079 {ECO:0000313|EMBL:EDN95848.1, ECO:0000313|Proteomes:UP000001312};
RN [1] {ECO:0000313|Proteomes:UP000001312}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18683 / 1980 / Ss-1 {ECO:0000313|Proteomes:UP000001312};
RX PubMed=21876677; DOI=.1371/journal.pgen.1002230;
RA Amselem J., Cuomo C.A., van Kan J.A., Viaud M., Benito E.P., Couloux A.,
RA Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.M.,
RA Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA Grossetete S., Guldener U., Henrissat B., Howlett B.J., Kodira C.,
RA Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA Zeng Q., Rollins J.A., Lebrun M.H., Dickman M.;
RT "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT sclerotiorum and Botrytis cinerea.";
RL PLoS Genet. 7:E1002230-E1002230(2011).
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DR EMBL; CH476639; EDN95848.1; -; Genomic_DNA.
DR RefSeq; XP_001587024.1; XM_001586974.1.
DR STRING; 665079.A7F2A6; -.
DR EnsemblFungi; EDN95848; EDN95848; SS1G_12053.
DR GeneID; 5483135; -.
DR KEGG; ssl:SS1G_12053; -.
DR eggNOG; KOG2128; Eukaryota.
DR HOGENOM; CLU_000972_1_1_1; -.
DR InParanoid; A7F2A6; -.
DR OMA; KGVLVHW; -.
DR OrthoDB; 12619at2759; -.
DR Proteomes; UP000001312; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR GO; GO:0110085; C:mitotic actomyosin contractile ring; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:1903479; P:mitotic actomyosin contractile ring assembly actin filament organization; IBA:GO_Central.
DR CDD; cd21206; CH_IQGAP; 1.
DR CDD; cd05127; RasGAP_IQGAP_like; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR14149:SF14; PATTERNED EXPRESSION SITE; 1.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 10.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 11.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001312}.
FT DOMAIN 315..421
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1169..1385
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1803 AA; 206022 MW; A5E44A824884D608 CRC64;
MSYRHLLRQT QSDSTTTANP NTTKRAPSNA STASSAYSNS SSVYELSRTS TLSSTTSSGY
GSHRKGLSEA TGMYTSSENR SGKGSIESSP DSAYKNVRKS LRPLAQPPGQ TSPERDKTPV
QHNRGKSVDM IRNNFQPHSR TQSVDVQKAP IKQHNRGKSI DVSKLTLFES PLQSPISPAI
SPTRSPTRRP PVVRPNSMLL SRSDSISIGG GALSKLGPLH PHTPLTRPEL QSFERSSTSQ
LRTLSKFAQT ATPDDFTITS PEQEVAGLHG RRRLQRSAIS KDKNGTLSKP TGGYGWEGRN
WMDKQRQFLQ AYEYLCHIGE AKEWIEDILK REIPPTVQLE QTLRDGVTLA EVVEALYPER
RIRIFRNPKL QARHWDNIAQ FFRFLDEVQL PELFRFELID LYEKKNIPKV IYCIHALSWL
LFRKGIVDFR IGNLVGQLEF EDHELEEMQK GLDKAGISMP SFGNMGADFG VPEPEPEPEP
VETEDERIDR ELGENEAIIV ELQAQVRGAC MRMHLGRTMQ VLWDTEDWLI DLQSMIRGDF
TRQVVEYRLN MKRFAENLQR HARGFLVRKR QSSQETFWKS HEEDVQKIQS LFRAKKVGQQ
VRDEVGMMRS ALQQSEFVVK DFQSSIRGFL ARKLLVAQQK ETESVTVSTP VLNLQAAVRG
MLVRKKMMEQ GEEISSITVS APVSDLQAAV RGMLVRKKMM KQGEEISSIT ASAPLSDLQA
AVKGMLVRKK MVAQENETSS VAVSTPVLNL QAAMRGMLLR KNIAEDQEDL YREESSITAI
QGFARALLTR NQIFEQQEAL HACTPIWEKL QAIARAGSLR NEVFDTQEAL KSHSGSISKL
QAFLRAGAVR REVTETLSGL DEEEPLILEL QSLIRGMLLR RSVEDDFDAL IAEVSAITDL
QSMVRAGMVR QKTEMILDDL QANEEEIIQL QALSRAVLLR NDIEGVLGEL ESEEDDIVAI
QSAAKASLVR AAFLEKQRFF KENMEKVVKI QSFVRGRLQG EAYKSLTTGK NPPVNTVKNF
VHLLNDSDFD FNEEIEFERM RKTVVQQVRQ NEMAEQYIDQ LDIKIALLVK NKITLDEVVK
HQRNFGGHSG NLLVNTSMAS GNQFDLKALN KNSRKKLELY QQLFFNLQTQ PQYLARLFQR
IREQGTAEKD CKRIETLMMG LFGYAQKRRE EYYLLKLIAR SAREEIEHFA SLQDFLRGNF
FWTKLLANYT RSPRDRKFLR DLLGPLIMEN IIEDPALDLE SDPMQIYRSA INNEELRTGR
PSQRALEIPR DQAIKDPETR DMFIDHLRDL REISDLFMLA LESLLHRMPY GVRFICQQIF
DGLCQQFPRE SQRNLLQLVG NWLFRFYLYP ALTTPESMGV VERQLTPLQK RNLGEVAKVL
GQISTGRLFG GENMFLQPLN AYVTDAIERI TDIFSNIISV QDAESTFDID EFNDLYARTK
PTLYIKMADI FAIHNLICDD LPQICPNRDD VLREIIQELG SAKSNESEML GVSSAEIQMT
LTPKLHDMED PEAEVKALFM ETKRCILYII RVQSGPNLME ILVRPISPED DQKWHDLLRE
EFSADSKTRG AYSDANTLTD IKSMSYWELK RTALENIMRL EQLGRISRQN YYQDILNAIA
VDIRTKSRRR VQRQRELEGV RMTLGNLGEK AEWLESQRKS YDNYIEQAMM TLQKKGVSLC
LSPKQYNHEK ELERTGRTYK FGSFKYSART LSDKGVLVAW KGYPEREWDK INLTISCDQV
GVFSIEGSKG SIVITGAVAQ VPMDSLLAAQ FANHQYMDMF EGAMRLNVNL FLHLLYRKFY
RTE
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