ID A7F6C9_SCLS1 Unreviewed; 600 AA.
AC A7F6C9;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=D-lactate dehydrogenase (cytochrome) {ECO:0000256|ARBA:ARBA00038897};
DE EC=1.1.2.4 {ECO:0000256|ARBA:ARBA00038897};
GN ORFNames=SS1G_13158 {ECO:0000313|EMBL:EDN98300.1};
OS Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)
OS (Whetzelinia sclerotiorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Sclerotinia.
OX NCBI_TaxID=665079 {ECO:0000313|EMBL:EDN98300.1, ECO:0000313|Proteomes:UP000001312};
RN [1] {ECO:0000313|Proteomes:UP000001312}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18683 / 1980 / Ss-1 {ECO:0000313|Proteomes:UP000001312};
RX PubMed=21876677; DOI=.1371/journal.pgen.1002230;
RA Amselem J., Cuomo C.A., van Kan J.A., Viaud M., Benito E.P., Couloux A.,
RA Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.M.,
RA Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA Grossetete S., Guldener U., Henrissat B., Howlett B.J., Kodira C.,
RA Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA Zeng Q., Rollins J.A., Lebrun M.H., Dickman M.;
RT "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT sclerotiorum and Botrytis cinerea.";
RL PLoS Genet. 7:E1002230-E1002230(2011).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH476643; EDN98300.1; -; Genomic_DNA.
DR RefSeq; XP_001586065.1; XM_001586015.1.
DR AlphaFoldDB; A7F6C9; -.
DR STRING; 665079.A7F6C9; -.
DR EnsemblFungi; EDN98300; EDN98300; SS1G_13158.
DR GeneID; 5482009; -.
DR KEGG; ssl:SS1G_13158; -.
DR eggNOG; KOG1231; Eukaryota.
DR HOGENOM; CLU_017779_3_2_1; -.
DR InParanoid; A7F6C9; -.
DR OMA; QKKFDTP; -.
DR OrthoDB; 1664005at2759; -.
DR Proteomes; UP000001312; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004458; F:D-lactate dehydrogenase (cytochrome) activity; IBA:GO_Central.
DR GO; GO:0008720; F:D-lactate dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR GO; GO:1903457; P:lactate catabolic process; IBA:GO_Central.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.2740; -; 1.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11748:SF111; D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001312}.
FT DOMAIN 167..346
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT REGION 25..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 600 AA; 65528 MW; D071FCCBC5B46E04 CRC64;
MYSARLQPII TGKLQPQFRI STSRIPGITQ TGIRNPYNSS FKSRCQSTKS KSKSKLNTST
PIPSSKPIPN STKSDAKNGW STERVLLLAA ATGGLAYAFA TMREKNRRGE VKDYADPAKF
TVPRYANIKD MEMALKEIRE ATHEDTISTD PEDLLAHGYS EWSSTNVDGL PVAVAYPKST
EEVSKITSIC HKYRVPIVPY SGGSSLEGNV SCPYGGVSVD FAFMDRIVEF HEEDMDIVVQ
PSVSWMDLNK ELARRKSGLF FPVDPGPSAK IGGMVGTNCS GTNCVRYGSM KDWVINLTVV
LSDGTIIKTK RRPRKSSAGY NLNSLFVGSE GTLGLVTEIT LKLAVVPPEY SVAVVTFPTI
RDAAAAAAGV MRAGIQVAAM EIMDEVQMKV VNLSKSTAPR QWKELPTLFF KFSGTKASVK
ENIAMVSAIA KSHRGSSFEF AKDAREQKLL WSARKESLWS MLALRKEGGE VWSTDVAVPF
SRLADIIELS KKEMDDLGLF ASILGHVGDG NFHESIMYDK TVAGEKDKVE KCVKNMVVRA
LEMEGTVTGE HGIGIGKKDS LLMELGHDTL GVMKSIKQAL GGYLFTFGFP LSSTLSLLSE
//
