ID A7GXF5_CAMC5 Unreviewed; 548 AA.
AC A7GXF5;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN Name=lctP {ECO:0000313|EMBL:EAU00755.1};
GN ORFNames=CCV52592_0467 {ECO:0000313|EMBL:EAU00755.1};
OS Campylobacter curvus (strain 525.92).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Campylobacteraceae; Campylobacter.
OX NCBI_TaxID=360105 {ECO:0000313|EMBL:EAU00755.1, ECO:0000313|Proteomes:UP000006380};
RN [1] {ECO:0000313|Proteomes:UP000006380}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=525.92 {ECO:0000313|Proteomes:UP000006380};
RA Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G.,
RA Mandrell R.E., Lastovica A.J., Nelson K.E.;
RT "Genome sequence of Campylobacter curvus 525.92 isolated from human
RT feces.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU365092};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU365092}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the lactate permease family.
CC {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
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DR EMBL; CP000767; EAU00755.1; -; Genomic_DNA.
DR RefSeq; WP_009649927.1; NC_009715.2.
DR AlphaFoldDB; A7GXF5; -.
DR STRING; 360105.CCV52592_0467; -.
DR KEGG; ccv:CCV52592_0467; -.
DR HOGENOM; CLU_021628_0_0_7; -.
DR OrthoDB; 9761056at2; -.
DR Proteomes; UP000006380; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR003804; Lactate_perm.
DR NCBIfam; TIGR00795; lctP; 1.
DR PANTHER; PTHR30003:SF0; GLYCOLATE PERMEASE GLCA; 1.
DR PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR Pfam; PF02652; Lactate_perm; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU365092};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW Reference proteome {ECO:0000313|Proteomes:UP000006380};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365092};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365092};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT TRANSMEM 15..34
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 41..59
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 65..92
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 119..147
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 199..217
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 295..314
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 353..375
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 395..412
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 432..457
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 517..536
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
SQ SEQUENCE 548 AA; 57891 MW; F67C5DC085ABA213 CRC64;
MQGYFLQNYD PAGNIWLSAL VAALPIFVFL LSLVALKLKG YVAAFLTVAA SAGVAVLFYK
MPVSAAFASF AYGFLYGLWP IAWIILCAIF LYKLSVNSGY FEALKTSITI ISPDHRIQVI
LIAFCFGSFL EGAIGFGAPV AISAALLMGL GLKPLSAAGL SMVANTAGAA FGAVGIPITA
LAGTVNLDPT IISTMTARML PPITFLVPFF LAFLVGGKFK DVLPHVTVAA ASYTITQYAT
AKFLGPELVN ITSAIVSIIL LSASVRIWKI KNIFRLDAAQ GEQNLEPPRL SVGQILKAWL
PFGFVIAAIV VWNLDAFKSA MSFADIKFEV PNLHNVVVQS APISEGEQAI AAVYSWGVIK
ATGTAILLAV VLTILALRIK FSVVLDSAKQ AGKEMSLPIV TIGLIVAYAY IAKYSGQAAT
MGLALSSTGN AFGFFSPIIG WLGVFLTGSV TSANLLFGTL QQVTANQLGV HEVIFLAANT
VGGVVGKIIS PQSIAVACAA VGMAGRESEV LKFTLKYSLI FIVLASAITW LVIHVFPQLV
PVVTDFIK
//
