ID A7HI96_ANADF Unreviewed; 1092 AA.
AC A7HI96;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Heavy metal efflux pump, CzcA family {ECO:0000313|EMBL:ABS28442.1};
GN OrderedLocusNames=Anae109_4264 {ECO:0000313|EMBL:ABS28442.1};
OS Anaeromyxobacter sp. (strain Fw109-5).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Anaeromyxobacteraceae; Anaeromyxobacter.
OX NCBI_TaxID=404589 {ECO:0000313|EMBL:ABS28442.1, ECO:0000313|Proteomes:UP000006382};
RN [1] {ECO:0000313|EMBL:ABS28442.1, ECO:0000313|Proteomes:UP000006382}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fw109-5 {ECO:0000313|EMBL:ABS28442.1,
RC ECO:0000313|Proteomes:UP000006382};
RX PubMed=25614562; DOI=10.1128/genomeA.01449-14;
RA Hwang C., Copeland A., Lucas S., Lapidus A., Barry K., Glavina Del Rio T.,
RA Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D.C.,
RA Detter J.C., Han C.S., Schmutz J., Larimer F.W., Land M.L., Hauser L.J.,
RA Kyrpides N., Lykidis A., Richardson P., Belieav A., Sanford R.A.,
RA Loeffler F.E., Fields M.W.;
RT "Complete genome sequence of Anaeromyxobacter sp. Fw109-5, an anaerobic,
RT metal-reducing bacterium isolated from a contaminated subsurface
RT environment.";
RL Genome Announc. 3:0-0(2015).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000769; ABS28442.1; -; Genomic_DNA.
DR RefSeq; WP_012099086.1; NC_009675.1.
DR AlphaFoldDB; A7HI96; -.
DR STRING; 404589.Anae109_4264; -.
DR KEGG; afw:Anae109_4264; -.
DR eggNOG; COG3696; Bacteria.
DR HOGENOM; CLU_002755_1_2_7; -.
DR OrthoDB; 9798415at2; -.
DR Proteomes; UP000006382; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF19; CATION EFFLUX SYSTEM PROTEIN CUSA; 1.
DR Pfam; PF00873; ACR_tran; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006382};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 340..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 914..931
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 938..958
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 964..988
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1023..1044
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1050..1069
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1092 AA; 120884 MW; E57813CB1775E7E6 CRC64;
MIKAIIRFSA ENKYLVVAAT LVALLGSAWA MRHIPLDAVP DLSDTQVIVY SKWDRSPDIV
EDQVTYPITT ALLGAPKVKA IRGFSDFGFS YVYVIFEDGT DMYWARTRVL EYLSKITPQL
PQGVTTELGP DATSVGWVYQ YALVDRTGRH SSDELRSFQD WFLRYAVQSV PGVSEVATVG
GQVRQYQITV NPNALATYKL PLDAVVNAVR TGNNDVGGRL VEFSGREYMV RGRGYVKSIA
DLENLVLRSE GGTPVLVKDV ATVALGPEMR RGVADLDGEG DVVGGIVVMR HGENALNVIE
RIEAKLEEVK PSLPEGVELV TTYDRSELIE EAISTVKHKL VEEIIVVSII ILVFLWHIPS
AIIPIITIPV SVALSFIPMY FMGINANLMS LAGIAISIGV LVDGAIVEVE NAYNKIHHWL
KDGRKGDFHH VRLEALLEVG PGVFFSLLVI AVAFMPVFTL VDQEGRLFRP LAFSKNLAMA
IAAFLAITLD PAMRMMFARI DDFTFKPRWL AWLANKALVG TYYSEEAHPI SRALHRVYEP
PCRFVLRHPR ATILASVLLV VTTIPVYLSL GSEFMPQLRE GTILYMPSAV EPGMSVAEAQ
QALQVQDKLL KTFPEVERVF GKAGRANTST DPAPFTMMET TLILKPQSEW REKPRWYSSW
APDWLKAVLR PIWNDRISHE ELENEMDAAL QLPGISNAWT MPIKGRLDML STGIRTPIGI
KISGADLKTI EQIAKETEAV VKKVPGTRSV YAERVAGGYF LDFVLKREQL ARYGLTVDDA
NMMVMTAVGG DNQSTTVEGR ERYGINVRYA RDYREDLSAL RRVLLPLPSG QGQIPMEEIA
DVVLAQGPAM IRNENGLLSG YVYVDFDTSK IDVGGYVDEA KKAVAAGVDL PTGYNMSWSG
QYENMLRVKE RLKLIIPITL VLIFGLLYMN TKSSFKAALV MAAVPFSAVG AVWLLWALDY
NVSIAVWVGI IALMGLDAET GVFMLLFLDL SHDEYKAKGL LRTRGDLVEA IVHGAVKRVR
PKAMTVFAAM LGLLPIMWSI GTGADVMKRI AAPMIGGLVT SFVMELLVYP PVYYLWKKKE
VSDEDTMTAI AA
//
