ID A7HJL0_FERNB Unreviewed; 632 AA.
AC A7HJL0;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=NADH dehydrogenase (Quinone) {ECO:0000313|EMBL:ABS60093.1};
DE EC=1.6.99.5 {ECO:0000313|EMBL:ABS60093.1};
GN OrderedLocusNames=Fnod_0226 {ECO:0000313|EMBL:ABS60093.1};
OS Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1).
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Fervidobacteriaceae;
OC Fervidobacterium.
OX NCBI_TaxID=381764 {ECO:0000313|EMBL:ABS60093.1, ECO:0000313|Proteomes:UP000002415};
RN [1] {ECO:0000313|EMBL:ABS60093.1, ECO:0000313|Proteomes:UP000002415}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35602 / DSM 5306 / Rt17-B1
RC {ECO:0000313|Proteomes:UP000002415};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C.,
RA Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.;
RT "Complete sequence of Fervidobacterium nodosum Rt17-B1.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABS60093.1, ECO:0000313|Proteomes:UP000002415}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35602 / DSM 5306 / Rt17-B1
RC {ECO:0000313|Proteomes:UP000002415};
RX PubMed=19307556; DOI=10.1073/pnas.0901260106;
RA Zhaxybayeva O., Swithers K.S., Lapierre P., Fournier G.P., Bickhart D.M.,
RA DeBoy R.T., Nelson K.E., Nesbo C.L., Doolittle W.F., Gogarten J.P.,
RA Noll K.M.;
RT "On the chimeric nature, thermophilic origin, and phylogenetic placement of
RT the Thermotogales.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5865-5870(2009).
CC -!- SIMILARITY: Belongs to the complex I 51 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00007523}.
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DR EMBL; CP000771; ABS60093.1; -; Genomic_DNA.
DR RefSeq; WP_011993416.1; NC_009718.1.
DR AlphaFoldDB; A7HJL0; -.
DR STRING; 381764.Fnod_0226; -.
DR KEGG; fno:Fnod_0226; -.
DR eggNOG; COG1894; Bacteria.
DR HOGENOM; CLU_014881_3_2_0; -.
DR OrthoDB; 9761899at2; -.
DR Proteomes; UP000002415; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR CDD; cd02980; TRX_Fd_family; 1.
DR Gene3D; 3.10.20.600; -; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 6.10.250.1450; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 3.40.50.11540; NADH-ubiquinone oxidoreductase 51kDa subunit; 1.
DR Gene3D; 1.20.1440.230; NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR001949; NADH-UbQ_OxRdtase_51kDa_CS.
DR InterPro; IPR011538; Nuo51_FMN-bd.
DR InterPro; IPR037225; Nuo51_FMN-bd_sf.
DR InterPro; IPR019575; Nuop51_4Fe4S-bd.
DR InterPro; IPR037207; Nuop51_4Fe4S-bd_sf.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR43578:SF2; FE-HYDROGENASE, SUBUNIT BETA; 1.
DR PANTHER; PTHR43578; NADH-QUINONE OXIDOREDUCTASE SUBUNIT F; 1.
DR Pfam; PF01257; 2Fe-2S_thioredx; 1.
DR Pfam; PF01512; Complex1_51K; 1.
DR Pfam; PF00037; Fer4; 2.
DR Pfam; PF10589; NADH_4Fe-4S; 1.
DR SMART; SM00928; NADH_4Fe-4S; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF142019; Nqo1 FMN-binding domain-like; 1.
DR SUPFAM; SSF142984; Nqo1 middle domain-like; 1.
DR SUPFAM; SSF140490; Nqo1C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
DR PROSITE; PS00645; COMPLEX1_51K_2; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000313|EMBL:ABS60093.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002415}.
FT DOMAIN 574..603
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 604..632
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 632 AA; 69283 MW; 6B7F4358086CB621 CRC64;
MAVAVERKFK NPADLLRYIE ELKIKREKKL QKTSIYVCVG TGCTASGSRK VYAKFVEVIN
QKGLDVNIEK IDDDDTPVKK TGCCGLCSLG PLVKIMPYGI TYSHVSVNDV EEIVERTLMK
GEAIERLLLT DPITDKKVER LEDATFFKNQ TFYIMEAIGT SECESIEDYM ARGGYTSLAK
VLSGMDRKEI IEQIKAAGLR GRGGGGFPTG LKWEAAYNSK GDIKYVVCNA DEGDPGAFMN
RTLLERDPHS VLEGMIIAAY TIGAQKGYAY IRAEYPIAVE MFNKAIEDAK EYGLLGENIL
GTDFSFELYV KEGAGAFVCG EETALLASIE GKRGVPRPRP PFPAQSGLWG KPTLINNVES
YANVPKIIRD GVENYRKRGV EKSPGTKMFS VTGPLKLTGI IEIQFGTTLR YILDNICGGT
SNGQKIKAIQ IGGPSGACLP EELFDLPLDY DTLKSVGAMV GSGGIVAITE DRCMVEVARF
FLDFTKRESC GKCVPCREGT TQAYNILEKF TQGKATYEDL ETLEQLSEII KTASLCGLGK
TAPNPIISTL KYFKNEYIEH IEGKCPSGMC TAFKKYIIIP EKCKSCSLCA RSCPNNAISG
ERGKPYVIDQ DKCIKCGLCV TKCKFGAIEL VG
//
