ID A7IL63_XANP2 Unreviewed; 535 AA.
AC A7IL63;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=AMP-dependent synthetase and ligase {ECO:0000313|EMBL:ABS68756.1};
GN OrderedLocusNames=Xaut_3527 {ECO:0000313|EMBL:ABS68756.1};
OS Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Xanthobacteraceae; Xanthobacter.
OX NCBI_TaxID=78245 {ECO:0000313|EMBL:ABS68756.1, ECO:0000313|Proteomes:UP000002417};
RN [1] {ECO:0000313|EMBL:ABS68756.1, ECO:0000313|Proteomes:UP000002417}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1158 / Py2 {ECO:0000313|Proteomes:UP000002417};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N.,
RA Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D.,
RA Detter J.C., Han C., Tapia R., Brainard J., Schmutz J., Larimer F.,
RA Land M., Hauser L., Kyrpides N., Kim E., Ensigns S.A., Richardson P.;
RT "Complete sequence of chromosome of Xanthobacter autotrophicus Py2.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; CP000781; ABS68756.1; -; Genomic_DNA.
DR AlphaFoldDB; A7IL63; -.
DR STRING; 78245.Xaut_3527; -.
DR KEGG; xau:Xaut_3527; -.
DR eggNOG; COG0365; Bacteria.
DR HOGENOM; CLU_000022_59_10_5; -.
DR OrthoDB; 9803968at2; -.
DR PhylomeDB; A7IL63; -.
DR Proteomes; UP000002417; Chromosome.
DR GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR CDD; cd05971; MACS_like_3; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR049515; MACS_put.
DR PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ABS68756.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002417}.
FT DOMAIN 37..397
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 447..525
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 535 AA; 57958 MW; 35A2FAF20881784B CRC64;
MLVPAADYQG LIRAFSWEIP GRFNMGVACA DAHADGSGKP ALIFVEESGP VRTYSFDELK
ALTNRFANAL VARGLKRGDR VAVFLPQAPE TAIAHIAAFK AGLISVPLFT LFGDEALEFR
LAASGARVLV TDLTGLAKLE RVRGHLPELE HVFVIGPDTG GASSFDAALE AASDRFIPVD
TGPDDPGIII FTSGTTGNPK GALHGHRVLL GHLPCIQFVH QYMPQPGDLH WTPADWAWIG
GLFDVLFPSL YLGVPVLAHR AKKFDPDAAM DLMARHQVRN VFLPPTALKL LRQADVRHDG
LKLRSLLTGG ETLGAELGAF VQERLGVEAR EIYGQTECNL VVGSNSSFFP IRPGAMGKAI
PGHDVRIVDD EGHELPTGEE GHIGIRRGDP VMMLEYWKNP EATAQKYAGD FLLTGDMGRQ
DEDGYLWYVG RSDDVITSAG YRIGPGEIED CILKHPAVAL VAVVGVPDPL RTEAVKAWVV
LKAGTTPSDA LAKEIQDFVK TRLSAHEYPR HVAFADTLPM TATGKILRRE LRARG
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