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Database: UniProt
Entry: A7IPH7_XANP2
LinkDB: A7IPH7_XANP2
Original site: A7IPH7_XANP2 
ID   A7IPH7_XANP2            Unreviewed;       289 AA.
AC   A7IPH7;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   08-MAY-2019, entry version 69.
DE   RecName: Full=Formyltetrahydrofolate deformylase {ECO:0000256|HAMAP-Rule:MF_01927};
DE            EC=3.5.1.10 {ECO:0000256|HAMAP-Rule:MF_01927};
DE   AltName: Full=Formyl-FH(4) hydrolase {ECO:0000256|HAMAP-Rule:MF_01927};
GN   Name=purU {ECO:0000256|HAMAP-Rule:MF_01927};
GN   OrderedLocusNames=Xaut_4704 {ECO:0000313|EMBL:ABS69923.1};
OS   Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Xanthobacteraceae; Xanthobacter.
OX   NCBI_TaxID=78245 {ECO:0000313|EMBL:ABS69923.1, ECO:0000313|Proteomes:UP000002417};
RN   [1] {ECO:0000313|EMBL:ABS69923.1, ECO:0000313|Proteomes:UP000002417}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1158 / Py2 {ECO:0000313|Proteomes:UP000002417};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D.,
RA   Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Brainard J.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Ensigns S.A., Richardson P.;
RT   "Complete sequence of chromosome of Xanthobacter autotrophicus Py2.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the hydrolysis of 10-formyltetrahydrofolate
CC       (formyl-FH4) to formate and tetrahydrofolate (FH4).
CC       {ECO:0000256|HAMAP-Rule:MF_01927}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-
CC         tetrahydrofolate + formate + H(+); Xref=Rhea:RHEA:19833,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740,
CC         ChEBI:CHEBI:57453, ChEBI:CHEBI:57454; EC=3.5.1.10;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01927};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.
CC       {ECO:0000256|HAMAP-Rule:MF_01927}.
CC   -!- SIMILARITY: Belongs to the PurU family. {ECO:0000256|HAMAP-
CC       Rule:MF_01927}.
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DR   EMBL; CP000781; ABS69923.1; -; Genomic_DNA.
DR   RefSeq; WP_012116674.1; NC_009720.1.
DR   STRING; 78245.Xaut_4704; -.
DR   EnsemblBacteria; ABS69923; ABS69923; Xaut_4704.
DR   KEGG; xau:Xaut_4704; -.
DR   eggNOG; ENOG4105CIY; Bacteria.
DR   eggNOG; COG0788; LUCA.
DR   HOGENOM; HOG000033576; -.
DR   KO; K01433; -.
DR   OMA; FLERHRC; -.
DR   OrthoDB; 979667at2; -.
DR   UniPathway; UPA00074; UER00170.
DR   Proteomes; UP000002417; Chromosome.
DR   GO; GO:0008864; F:formyltetrahydrofolate deformylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016742; F:hydroxymethyl-, formyl- and related transferase activity; IEA:InterPro.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd08648; FMT_core_Formyl-FH4-Hydrolase_; 1.
DR   HAMAP; MF_01927; PurU; 1.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR041729; Formyl-FH4-Hydrolase_C.
DR   InterPro; IPR002376; Formyl_transf_N.
DR   InterPro; IPR036477; Formyl_transf_N_sf.
DR   InterPro; IPR004810; PurU.
DR   PANTHER; PTHR42706; PTHR42706; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00551; Formyl_trans_N; 1.
DR   PRINTS; PR01575; FFH4HYDRLASE.
DR   SUPFAM; SSF53328; SSF53328; 1.
DR   TIGRFAMs; TIGR00655; PurU; 1.
DR   PROSITE; PS51671; ACT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002417};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01927};
KW   One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_01927};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_01927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002417}.
FT   DOMAIN        9     82       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   ACT_SITE    232    232       {ECO:0000256|HAMAP-Rule:MF_01927}.
SQ   SEQUENCE   289 AA;  32673 MW;  76FBA36FD29C4250 CRC64;
     MTTPSDHFIL TFSCPNKPGI VAGVSTFLFE KGCNILEAQQ FDDTETNRFF MRVVFNVVAS
     EASLSEIREG FTAVAEGFAL NWTLRPKAEK RRVLLLASKF DHCLADLLYR WRIGEIPMDI
     TGIISNHPRE TYAHLDFDGI PFHHLPVTKA TKLEQETKIW EIFQSSGSEL AVLARYMQVL
     SDGLTAKLSG KCINIHHSFL PGFKGAKPYH QAHARGVKLM GATSHYVTSD LDEGPIIEQD
     VERISHQDSP EDLVRKGRDI ERRVLARAIS WHLQDRVLLN GSRTVVFRD
//
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