ID   A7J149_PIG              Unreviewed;       472 AA.
AC   A7J149; F1S504;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   SubName: Full=BPI fold containing family B member 1 {ECO:0000313|Ensembl:ENSSSCP00000007732.2};
DE   SubName: Full=Long palate lung and nasal epithelium protein 1 {ECO:0000313|EMBL:ABI64140.1};
GN   Name=BPIFB1 {ECO:0000313|Ensembl:ENSSSCP00000007732.2,
GN   ECO:0000313|VGNC:VGNC:95739};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|EMBL:ABI64140.1};
RN   [1] {ECO:0000313|EMBL:ABI64140.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Rosenkilde C., Jorgensen C.B., Cierra S.S., Mortensen P.K., Fredholm M.;
RT   "Cloning and expression analysis of PLUNC gene family in pig.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000007732.2, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000007732.2,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSSSCP00000007732.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; DQ859015; ABI64140.1; -; mRNA.
DR   RefSeq; NP_001094502.1; NM_001101032.1.
DR   STRING; 9823.ENSSSCP00000007732; -.
DR   PaxDb; 9823-ENSSSCP00000007732; -.
DR   Ensembl; ENSSSCT00000007945.4; ENSSSCP00000007732.2; ENSSSCG00000007261.5.
DR   GeneID; 100113426; -.
DR   KEGG; ssc:100113426; -.
DR   CTD; 92747; -.
DR   VGNC; VGNC:95739; BPIFB1.
DR   eggNOG; KOG4160; Eukaryota.
DR   GeneTree; ENSGT01100000263546; -.
DR   HOGENOM; CLU_050473_0_0_1; -.
DR   OMA; ELCPVIK; -.
DR   OrthoDB; 5262309at2759; -.
DR   TreeFam; TF338541; -.
DR   Reactome; R-SSC-6803157; Antimicrobial peptides.
DR   Proteomes; UP000008227; Chromosome 17.
DR   Bgee; ENSSSCG00000007261; Expressed in lung and 2 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR   GO; GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; IBA:GO_Central.
DR   CDD; cd00025; BPI1; 1.
DR   CDD; cd00026; BPI2; 1.
DR   InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR   InterPro; IPR021193; Bpifb1.
DR   InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR   InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR   PANTHER; PTHR47395; BPI FOLD-CONTAINING FAMILY B MEMBER 1; 1.
DR   PANTHER; PTHR47395:SF1; BPI FOLD-CONTAINING FAMILY B MEMBER 1; 1.
DR   Pfam; PF01273; LBP_BPI_CETP; 1.
DR   Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR   PIRSF; PIRSF037186; PLUNC_long_form; 1.
DR   SMART; SM00328; BPI1; 1.
DR   SUPFAM; SSF55394; Bactericidal permeability-increasing protein, BPI; 2.
PE   2: Evidence at transcript level;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..472
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015086554"
FT   DOMAIN          36..254
FT                   /note="Lipid-binding serum glycoprotein N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00328"
SQ   SEQUENCE   472 AA;  51957 MW;  14D9973E98AF4B35 CRC64;
     MANPRIFTFL CGLLATHLVA ATLCPPVVLR LGPEVIKEKL TQKLKDRDAV HVLQQLPLLD
     AMQESSQGVL ARLVSSILKY ITWLKVTSAS ILQLQVQPLP NGQELLVKIP LDMVAGLNTP
     LVKTIVELHM QVEVEAIIHV ETSETGEDQL VLSNCSNTRG SLRISLLHKL SFLLNSIAEK
     VIKLLVPALP KVVKGELCPV LREAFEDVRA DLLNLVKLPT SLKSDRLEFE LLSQAIEGSA
     VQLNLGAKLL DSDGNVIMLF NDTVDSLNLP PLSDVPFSLI VRKDVVNAAV VAFLPPEELM
     VLLDYVLPEL AHRLKLSIKA ISEKAADKLE PTQIVKILTQ DTPEFLVDQG NAKVAQLIVL
     EVFPTNEDRR PLFTLGIEAT SEAQFYTEDD RLMLNLYDLS SDRIHLMNSD IGLFNPELLK
     DIITEILISV LLPNENGKLR SGIPVSMVKA LGYETASWSL IKDALVVTPA SS
//