ID A7KQ40_9ALPH Unreviewed; 441 AA.
AC A7KQ40;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Virion host shutoff protein {ECO:0000256|ARBA:ARBA00018606};
GN ORFNames=MDV054 {ECO:0000313|EMBL:ABR13126.1};
OS Gallid alphaherpesvirus 2.
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Mardivirus;
OC Mardivirus gallidalpha2.
OX NCBI_TaxID=10390 {ECO:0000313|EMBL:ABR13126.1, ECO:0000313|Proteomes:UP000143489};
RN [1] {ECO:0000313|EMBL:ABR13126.1, ECO:0000313|Proteomes:UP000143489}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RB-1B {ECO:0000313|EMBL:ABR13126.1};
RX PubMed=17721813; DOI=10.1007/s11262-007-0157-1;
RA Spatz S.J., Zhao Y., Petherbridge L., Smith L.P., Baigent S.J., Nair V.;
RT "Comparative sequence analysis of a highly oncogenic but horizontal spread-
RT defective clone of Marek's disease virus.";
RL Virus Genes 35:753-766(2007).
RN [2] {ECO:0000313|EMBL:QOT14034.1}
RP NUCLEOTIDE SEQUENCE.
RA Conradie A.M., Bertzbach L.D., Trimpert J.D., Patria J.N., Murata S.,
RA Parcells M.S., Kaufer B.B.;
RT "Distinct polymorphisms in a single herpesvirus gene are capable of
RT enhancing virulence and mediate vaccinal resistance.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QOT14220.1}
RP NUCLEOTIDE SEQUENCE.
RA Conradie A.M., Bertzbach L.D., Trimpert J., Patria J.N., Murata S.,
RA Parcells M.S., Kaufer B.B.;
RT "Distinct polymorphisms in a single herpesvirus gene are capable of
RT enhancing virulence and mediate vaccinal resistance.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:QOT14770.1}
RP NUCLEOTIDE SEQUENCE.
RA Conradie A.M., Kaufer B.;
RT "Marek's disease virus requires both copies of the inverted repeat regions
RT for efficient in vivo replication and pathogenesis.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:QOT14903.1}
RP NUCLEOTIDE SEQUENCE.
RA Vychodil T., Conradie A.M., Trimpert J., Aswad A., Bertzbach L.D.,
RA Kaufer B.;
RT "Functional analysis of genomic repeat regions in Marek's disease virus
RT replication and pathogenesis.";
RL Submitted (SEP-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328}.
CC -!- SIMILARITY: Belongs to the herpesviridae VHS protein family.
CC {ECO:0000256|ARBA:ARBA00009669}.
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DR EMBL; EF523390; ABR13126.1; -; Genomic_DNA.
DR EMBL; MT797629; QOT14034.1; -; Genomic_DNA.
DR EMBL; MT797630; QOT14220.1; -; Genomic_DNA.
DR EMBL; MT797631; QOT14406.1; -; Genomic_DNA.
DR EMBL; MT813453; QOT14589.1; -; Genomic_DNA.
DR EMBL; MT872313; QOT14770.1; -; Genomic_DNA.
DR EMBL; MT955328; QOT14903.1; -; Genomic_DNA.
DR EMBL; MT994392; QOT15043.1; -; Genomic_DNA.
DR Proteomes; UP000143489; Genome.
DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0039595; P:induction by virus of catabolism of host mRNA; IEA:UniProtKB-KW.
DR GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR Pfam; PF00867; XPG_I; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 3: Inferred from homology;
KW Decay of host mRNAs by virus {ECO:0000256|ARBA:ARBA00022616};
KW Eukaryotic host gene expression shutoff by virus
KW {ECO:0000256|ARBA:ARBA00023247};
KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW Host mRNA suppression by virus {ECO:0000256|ARBA:ARBA00022557};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Virion {ECO:0000256|ARBA:ARBA00022844}.
FT DOMAIN 166..209
FT /note="XPG-I"
FT /evidence="ECO:0000259|Pfam:PF00867"
SQ SEQUENCE 441 AA; 50399 MW; 4C36054A103079F9 CRC64;
MGVYGCMNFA YANGLVRSHI SGFISGGDMT PIAVDLWNVM YGLLEKLYPG KIDGVDDSII
TLRCLYCLLR LLHQRSYYPV FVADRGFYGN GKTLYGAKAI AATCIATRGG SGRLHARLFD
ECGSTDVGEA RCKRKHPGEK VCRWSERFET PKILYQLCMS IIRYMGYPYV DAGTMEADDI
CANLFHTKTV AYVLSSDTDL ILMGCDIIID LTRIFPPTIY CRDVLAALQM DYFTFLLNFV
RCHTDLHREP TLKSMQEIIN LSSAKRCLHD TDCATDDDVP RCIRPLYEEQ DRRTGENSYH
SEGFDLHIRK DQSKTSCWDN DVSNYTDTNL IRGVQKALKS LRPPRTRCEI LEYKFIKHVI
ATIIPERRTS RVSILKRFPI MQEGRDETAV EDLIFCNIFD VDEASTIVSQ FIKRIPEVRP
LNHILLKYWG NDALKTTRSN D
//
