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Database: UniProt
Entry: A7MHW0_CROS8
LinkDB: A7MHW0_CROS8
Original site: A7MHW0_CROS8 
ID   A7MHW0_CROS8            Unreviewed;       356 AA.
AC   A7MHW0;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   08-MAY-2019, entry version 68.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   OrderedLocusNames=ESA_00653 {ECO:0000313|EMBL:ABU75936.1};
OS   Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Cronobacter.
OX   NCBI_TaxID=290339 {ECO:0000313|EMBL:ABU75936.1, ECO:0000313|Proteomes:UP000000260};
RN   [1] {ECO:0000313|EMBL:ABU75936.1, ECO:0000313|Proteomes:UP000000260}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-894 {ECO:0000313|EMBL:ABU75936.1,
RC   ECO:0000313|Proteomes:UP000000260};
RX   PubMed=20221447; DOI=10.1371/journal.pone.0009556;
RA   Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L.,
RA   Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D.,
RA   Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K.,
RA   Wilson R.K., McClelland M., Forsythe S.J.;
RT   "Genome sequence of Cronobacter sakazakii BAA-894 and comparative
RT   genomic hybridization analysis with other Cronobacter species.";
RL   PLoS ONE 5:E9556-E9556(2010).
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; CP000783; ABU75936.1; -; Genomic_DNA.
DR   RefSeq; WP_012124001.1; NC_009778.1.
DR   EnsemblBacteria; ABU75936; ABU75936; ESA_00653.
DR   KEGG; esa:ESA_00653; -.
DR   PATRIC; fig|290339.8.peg.578; -.
DR   eggNOG; ENOG4105E99; Bacteria.
DR   eggNOG; COG0722; LUCA.
DR   HOGENOM; HOG000220501; -.
DR   KO; K01626; -.
DR   OMA; VMENVAN; -.
DR   OrthoDB; 853329at2; -.
DR   BioCyc; CSAK290339:G1G9O-606-MONOMER; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000000260; Chromosome.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000260};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       38    340       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   356 AA;  38752 MW;  29AA43F7ACDCB711 CRC64;
     MQKDALNNVH IADEQVLITP DQLKAQFPLT VEQEAQIARS RQTISDIIAG RDPRLLVVCG
     PCSIHDPEAA MEYARRFKTL SEQVSDSLYL VMRVYFEKPR TTVGWKGLIN DPHMDGSFDV
     EAGLKIARRL LVDLVSLGLP LATEALDPNS PQYLGDLFSW SAIGARTTES QTHREMASGL
     SMPVGFKNGT DGSLATAINA MRAAAMPHRF VGINQAGQVC LLQTQGNPDG HVILRGGKAP
     NYSPADVAQC EKEMAQAGLR PALMIDCSHG NSNKDYRRQP GVAESAVAQI KDGNRSIIGL
     MIESHLHEGN QSSEQPRSAM KYGVSVTDAC ISWETTEALL RELHQDLRGA LAARLA
//
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