ID A7MPJ3_CROS8 Unreviewed; 334 AA.
AC A7MPJ3;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=2-keto-3-deoxygluconate permease {ECO:0000256|HAMAP-Rule:MF_00070};
DE Short=KDG permease {ECO:0000256|HAMAP-Rule:MF_00070};
GN Name=kdgT {ECO:0000256|HAMAP-Rule:MF_00070};
GN OrderedLocusNames=ESA_00135 {ECO:0000313|EMBL:ABU75440.1};
OS Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Cronobacter.
OX NCBI_TaxID=290339 {ECO:0000313|EMBL:ABU75440.1, ECO:0000313|Proteomes:UP000000260};
RN [1] {ECO:0000313|EMBL:ABU75440.1, ECO:0000313|Proteomes:UP000000260}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-894 {ECO:0000313|EMBL:ABU75440.1,
RC ECO:0000313|Proteomes:UP000000260};
RX PubMed=20221447; DOI=10.1371/journal.pone.0009556;
RA Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L.,
RA Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A.,
RA Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K.,
RA McClelland M., Forsythe S.J.;
RT "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic
RT hybridization analysis with other Cronobacter species.";
RL PLoS ONE 5:E9556-E9556(2010).
CC -!- FUNCTION: Catalyzes the proton-dependent uptake of 2-keto-3-
CC deoxygluconate (KDG) into the cell. {ECO:0000256|HAMAP-Rule:MF_00070}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) = 2-dehydro-3-
CC deoxy-D-gluconate(out) + H(+)(out); Xref=Rhea:RHEA:29943,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57990; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_00070};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC Rule:MF_00070}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_00070}.
CC -!- SIMILARITY: Belongs to the KdgT transporter family.
CC {ECO:0000256|ARBA:ARBA00006430, ECO:0000256|HAMAP-Rule:MF_00070}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_00070}.
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DR EMBL; CP000783; ABU75440.1; -; Genomic_DNA.
DR AlphaFoldDB; A7MPJ3; -.
DR KEGG; esa:ESA_00135; -.
DR HOGENOM; CLU_057476_0_1_6; -.
DR Proteomes; UP000000260; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015649; F:2-keto-3-deoxygluconate:proton symporter activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00070; KdgT; 1.
DR InterPro; IPR004684; 2keto-3dGluconate_permease.
DR InterPro; IPR018395; 2keto-3dGluconate_permease_sub.
DR NCBIfam; TIGR00793; kdgT; 1.
DR Pfam; PF03812; KdgT; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_00070};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_00070};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00070};
KW Reference proteome {ECO:0000313|Proteomes:UP000000260};
KW Sugar transport {ECO:0000256|HAMAP-Rule:MF_00070};
KW Symport {ECO:0000256|HAMAP-Rule:MF_00070};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_00070};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_00070};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_00070}.
FT TRANSMEM 47..65
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 77..98
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 104..130
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 142..165
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 171..188
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 200..219
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 225..244
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 256..277
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 289..311
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
SQ SEQUENCE 334 AA; 34382 MW; 5AEFF688911E0558 CRC64;
MMKIKATMER IPGGMMLIPL LLGAILNTLA PETGNYFGSF TKGMISGTVP VLAVWFFCIG
ASIDLRATGT VLRKSGTLVL TKIAVAWLVA MIAASFIPDT GIQTGFFAGL SVLAIVSAMD
MTNGGLYASL MNQYGTKEES GAFVLMSLES GPLMTMVILG SAGLASFEPH HFIGAVLPFL
IGFALGNLDH DLRAFFSKAT PVLIPFFGFA LGNTINLRVI LETGLLGIVL GVAVIIITGI
PLIMADKFLG GGNGTAGVAA SSAAGAAVAN PVIIAQINPA FEPVAAQATA LVAASVIVTA
ILVPIITALY ARHVAKQAPA VAHAESVSTS TLHR
//
