ID A7RGG4_NEMVE Unreviewed; 760 AA.
AC A7RGG4;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=CSC1-like protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=NEMVEDRAFT_v1g177567 {ECO:0000313|EMBL:EDO49424.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO49424.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO49424.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; DS469509; EDO49424.1; -; Genomic_DNA.
DR RefSeq; XP_001641487.1; XM_001641437.1.
DR AlphaFoldDB; A7RGG4; -.
DR STRING; 45351.A7RGG4; -.
DR EnsemblMetazoa; EDO49424; EDO49424; NEMVEDRAFT_v1g177567.
DR GeneID; 5521707; -.
DR KEGG; nve:5521707; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_015647_0_0_1; -.
DR InParanoid; A7RGG4; -.
DR OMA; QGIGMFP; -.
DR OrthoDB; 231434at2759; -.
DR PhylomeDB; A7RGG4; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR PANTHER; PTHR13018:SF153; RE44586P; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 552..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..157
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 174..347
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 358..599
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 702..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 760 AA; 86004 MW; D00623E85CCEDBA3 CRC64;
MVLFCVIRRL VWDYGRLAVT QKEDLGWTSV FYGLNVNGNG KDKQEDKPSV TFPEVKDKGL
LSWVPVLLRV TDEHIHVKCG MDALQYIQFQ KHLIVYSVII FCLSIGIVLP INYSGTNEYE
RNSFGATTVS NLEAQSSMFW LHAVFALLYI IIIVVILRHF TSLFNMESLH ESATTVMITN
IPKNVTKELI QQHFVEVYDD SMIEEVQLAY NCDKLQSIER KLEAARLGRE HCQELLQLNG
ERPQTTVSTS KVSPCMMCCG VKHVDGIEYF TEVEGKARVE FEQTKQSLKS LGVAFVTFVN
EETSQKCLKD FNTIKHGSPE SSVSRKIFSD HWNVASAPLT GDILWEHLSV DPESWWARAL
IINIILFIFV LFITTPTVLI TSFNEIKASI VEKNPKLRVA PNPFFTQFLP TIMLWTFSAI
LPVVVSYSSY FEAHWTRSRL EHSVMIKTYV FLLLMVIVLP SLALTSADAL FQVTLSGSAL
LKSRLACVFL PNNGAFFVNY LVTSALIGTA LELCRFPELA AYAVRMCFAK DEGEKRLVRR
ESVREFAFGH QYAWMIVIFS VMVVYSIACP LVTPFGLLYL TFKHVVDRYN LYFNYRSPAY
KYVDPSVHST AVVFTIISSF FLLLSILFFG VVRLGINDPQ TIFTIVLVAL TLAAFVGRVA
FGFFKRLGPF KQRLNNDEED HITEVYMPEA YLPPVLRSKR ESAAASAGED SSPPQLTRRK
TYGTTSPTVP YSGAADHVID ADQLTPSSET IVSMSEEERR
//
