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Database: UniProt
Entry: A7RH52_NEMVE
LinkDB: A7RH52_NEMVE
Original site: A7RH52_NEMVE 
ID   A7RH52_NEMVE            Unreviewed;      1092 AA.
AC   A7RH52;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   05-JUN-2019, entry version 78.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=v1g233970 {ECO:0000313|EMBL:EDO49294.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO49294.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J.,
RA   Salamov A., Terry A., Shapiro H., Lindquist E., Kapitonov V.V.,
RA   Jurka J., Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E.,
RA   Finnerty J.R., Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; DS469510; EDO49294.1; -; Genomic_DNA.
DR   RefSeq; XP_001641357.1; XM_001641307.1.
DR   STRING; 45351.EDO49294; -.
DR   EnsemblMetazoa; EDO49294; EDO49294; NEMVEDRAFT_v1g233970.
DR   GeneID; 5521437; -.
DR   KEGG; nve:NEMVE_v1g233970; -.
DR   eggNOG; KOG0968; Eukaryota.
DR   eggNOG; COG0417; LUCA.
DR   HOGENOM; HOG000036616; -.
DR   InParanoid; A7RH52; -.
DR   KO; K02327; -.
DR   OMA; CLVNYTE; -.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0043625; C:delta DNA polymerase complex; IBA:GO_Central.
DR   GO; GO:0008296; F:3'-5'-exodeoxyribonuclease activity; IBA:GO_Central.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006287; P:base-excision repair, gap-filling; IBA:GO_Central.
DR   GO; GO:0045004; P:DNA replication proofreading; IBA:GO_Central.
DR   GO; GO:0006261; P:DNA-dependent DNA replication; IBA:GO_Central.
DR   GO; GO:0006297; P:nucleotide-excision repair, DNA gap filling; IBA:GO_Central.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001593};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      110    467       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      532    960       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      999   1070       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     71       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A7RH52}.
FT   COMPBIAS      1     19       Polar. {ECO:0000256|MobiDB-lite:A7RH52}.
SQ   SEQUENCE   1092 AA;  122896 MW;  0EDEE753D7E4A4F5 CRC64;
     MDSSQKRKGA FGTGNASKRS RNQDDLDGSQ PSSFESELAS LQGDDGAVET ATRGRPSDKW
     PRPALPPFEP ASDNIQFQQL DVENYIGTPL LGMPGSKVGP VPIIRMFGVT MDGNSVLCHI
     HGFVPYFFVP APPGFQEIHC SLFRDTLDKA VLNDMRSNRD GVTQAVLAVD YMMRESIYGY
     HKNTKIPFLK VTVALQKLIA PAKRILETGF RCGHYPERGY STYESNIDYE VRFMVDSDIV
     GCNWIELPAG KYRVRTPNGI ASRYRSSAKP ESRCQLEVDV AWDELISHEP EGDWSKIAPV
     RILSFDIECA GRKGIFPEAE KDPVIQIANM VIRQGEKDPF IRNVFTLGGC APIVGSHVLS
     FDKEADLFKA WSEFVQECDP DIITGYNIVN FDLPYLLNRA TALHVNNFSL LGRIVADKST
     VTSTTFQSKA YGKRENKVIN ISGRVQFDLL HVLLRDYKLR SYTLNAVSFH FLQEQKEDVQ
     HNIISDLQNG NDQTRRRLAI YCMKDAILPL RLLEKLMCVI NYMEMARVTG VPMGYLLSRG
     QQIKVMSQLL RKTHQTDLVI PAHKAEAGEE YAGATVIEPN KGYYNIPIAT LDFSSLYPSI
     MMAHNLCYTS LLHPSQVKET PPDQYIKTPS GNFFVKKSVR KGLLPEILEH LLTARKKAKA
     DLKKETDPFK KKVLDGRQLA LKISANSVYG FTGAQVGKLP CLEISQSVTA FGRMMIERTK
     ELVEAKYTVA NGYKTDAKVI YGDTDSVMVR FGVETVAESM ELGNEAAEYV SEHFVKPIKL
     EFEKVYFPYL LISKKRYAGL YFTKPDKHDK MDCKGIETVR RDNCPLVANL INACLKKLLI
     ERNPQGAVEY TKQVISDLLC NRIDISQLVI TKELTKTGEE YAGKQAHSEL AERMRKRDAG
     SAPKLGDRVP YVIIAGAKGA KAYEKAEDPI YVLENNVPID TGYYLENQLS KPLLRIFEPI
     LGESKASSAL LKGEHTRTKT IVTSTVGKLS MFTKKRSTCI GCKALLDDDG SAVCKHCKSR
     ESELFQKEIE HLRVLEERFA RLWTQCQNCT GSLHQDVLCT SRDCPIFYMR TKVQKDLANQ
     DKQVSRFGDC FW
//
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