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Database: UniProt
Entry: A7RHA4_NEMVE
LinkDB: A7RHA4_NEMVE
Original site: A7RHA4_NEMVE 
ID   A7RHA4_NEMVE            Unreviewed;       615 AA.
AC   A7RHA4;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   05-JUN-2019, entry version 91.
DE   SubName: Full=Predicted protein {ECO:0000313|EMBL:EDO49191.1};
DE   Flags: Fragment;
GN   ORFNames=v1g31143 {ECO:0000313|EMBL:EDO49191.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO49191.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J.,
RA   Salamov A., Terry A., Shapiro H., Lindquist E., Kapitonov V.V.,
RA   Jurka J., Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E.,
RA   Finnerty J.R., Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
CC         tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC         EC=2.7.10.1; Evidence={ECO:0000256|SAAS:SAAS01124082};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. {ECO:0000256|SAAS:SAAS00602168}.
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DR   EMBL; DS469510; EDO49191.1; -; Genomic_DNA.
DR   RefSeq; XP_001641254.1; XM_001641204.1.
DR   STRING; 45351.EDO49191; -.
DR   EnsemblMetazoa; EDO49191; EDO49191; NEMVEDRAFT_v1g31143.
DR   GeneID; 5521468; -.
DR   KEGG; nve:NEMVE_v1g31143; -.
DR   eggNOG; KOG0200; Eukaryota.
DR   eggNOG; COG0515; LUCA.
DR   HOGENOM; HOG000263410; -.
DR   InParanoid; A7RHA4; -.
DR   KO; K05094; -.
DR   OMA; YPEKMEK; -.
DR   OrthoDB; 220433at2759; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 2.
DR   SMART; SM00406; IGv; 2.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50835; IG_LIKE; 2.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00600564};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001593};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00941986};
KW   Kinase {ECO:0000256|SAAS:SAAS00598388};
KW   Membrane {ECO:0000256|SAAS:SAAS00602125, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00600689};
KW   Receptor {ECO:0000256|SAAS:SAAS00600436};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW   Transferase {ECO:0000256|SAAS:SAAS00602511};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00600943,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
KW   ECO:0000256|SAM:Phobius};
KW   Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00293420}.
FT   TRANSMEM    219    242       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       12     86       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN       95    193       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      323    609       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:EDO49191.1}.
FT   NON_TER     615    615       {ECO:0000313|EMBL:EDO49191.1}.
SQ   SEQUENCE   615 AA;  69582 MW;  5B59652A765DBA1D CRC64;
     KREKTLIAMP VGNSLKLDCS ADGKPRPTVV WLKNGKPFLK RDGVELSLRP YQYVLSMRDA
     VPSDDGRYTC NVSNALGWIN HTYTVDVRER VRAKPVLQPI ANVTVLSGEN ATLECKAMSD
     SMPHFQWIRW FTARVNGSSN ETTLRFEVVK QTPHSDHILR PKSEHRFAFH GVKLTLFNVS
     KEDEGKYTCL VGNAVGYNAE NGYLIVKGMI TNDGVTKKIV IIVVVVSVIA LVIFIFIAYG
     CYVKHKMGPK TKQNIQYTTA NIEPASPFQR NHSMRTSTSS YGSTVPLLAR ERSMRSRLGS
     NLSQVSEIEL PLDEEWELDR SQISLLGILG EGAFGRVVKA DAIGLPNMPY RCNVAVKMLK
     EDATEHELAD LVSEMEVMKT IGQHVNIINL IGACTQKGPL FVVVEYASQG NLRQFLRARR
     PIPEYANPLT EPPREKLKLV DLVSFSYQVA RGMEYLESKK CIHRDLAARN VLVSDNHVIK
     IADFGLARDI HDIDYYRKTT DGRLPVKWMA LEALFDRVYT AQSDVWAYGI LMWEIVTFGG
     SPYPGIPLWK LFELLKEGYR MEQPVNCQDD VYALMLRCWH ENPNQRPTFA EIVKEMDAKL
     TALSEQEYLD LTSPL
//
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