ID A7RI02_NEMVE Unreviewed; 495 AA.
AC A7RI02;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000259|PROSITE:PS50042};
DE Flags: Fragment;
GN ORFNames=NEMVEDRAFT_v1g82457 {ECO:0000313|EMBL:EDO49064.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO49064.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO49064.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel HCN family.
CC {ECO:0000256|ARBA:ARBA00006305}.
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DR EMBL; DS469511; EDO49064.1; -; Genomic_DNA.
DR RefSeq; XP_001641127.1; XM_001641077.1.
DR AlphaFoldDB; A7RI02; -.
DR EnsemblMetazoa; EDO49064; EDO49064; NEMVEDRAFT_v1g82457.
DR GeneID; 5521210; -.
DR KEGG; nve:5521210; -.
DR eggNOG; KOG0498; Eukaryota.
DR HOGENOM; CLU_005746_15_2_1; -.
DR InParanoid; A7RI02; -.
DR OMA; ILIDEWH; -.
DR OrthoDB; 74296at2759; -.
DR PhylomeDB; A7RI02; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0098855; C:HCN channel complex; IBA:GO_Central.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0003254; P:regulation of membrane depolarization; IBA:GO_Central.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013621; Ion_trans_N.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF5; I[[H]] CHANNEL, ISOFORM E; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08412; Ion_trans_N; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 3: Inferred from homology;
KW cAMP {ECO:0000256|ARBA:ARBA00023149};
KW cAMP-binding {ECO:0000256|ARBA:ARBA00022566};
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022566};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT TRANSMEM 38..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 368..485
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDO49064.1"
FT NON_TER 495
FT /evidence="ECO:0000313|EMBL:EDO49064.1"
SQ SEQUENCE 495 AA; 56996 MW; FEBAFA46AB571756 CRC64;
DNKLALKLFG NKAAVMLEQR RQSQQGKGVI HPFSTFRWYW DILLIIFIFM HVLLLPVSIA
FLSDDLSIHW LILNGVSDVF FVVDIFLNFR TGIVDPNNQE EVILDKKVIS MMYLRGWFII
DLASSLPFDY AYFIASSTTE EQTLLRASRA LRILKLAKLL SLLRLLRVSR LVRYMTRFEE
LLNIAKGQLR IMKLICCMLV LSHWNGCIQF FVPYLQEFPD DSWVSTSNLK TASPGEQYSW
SLFRALSHML CIGYGHYPPQ NLTDLWLTVC SMTAGATFYA VFIGIMSSLI MSIDSSGRLF
NEKLNQVEEY MRYRKLPLRI RLQVQDFYEH RFHHKLFDED AILTELSKNL RETILVHNIK
PLLTTVPFFS GASISFITDI VTKLKFEVFL NGDYICRSGH RGDKMYFIQK GIVDILTREG
ALATSLGDGS HFGEICLLTK EARRVASVRA ATTCDVYSLS ATHFHEVLQD YPEMKSVLEE
VAKERLSRLG LKPKL
//
