ID A7RJ05_NEMVE Unreviewed; 315 AA.
AC A7RJ05;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=PLAT domain-containing protein {ECO:0000259|PROSITE:PS50095};
GN ORFNames=NEMVEDRAFT_v1g83119 {ECO:0000313|EMBL:EDO48598.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO48598.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO48598.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS469513; EDO48598.1; -; Genomic_DNA.
DR RefSeq; XP_001640661.1; XM_001640611.1.
DR AlphaFoldDB; A7RJ05; -.
DR STRING; 45351.A7RJ05; -.
DR MEROPS; P02.038; -.
DR EnsemblMetazoa; EDO48598; EDO48598; NEMVEDRAFT_v1g83119.
DR eggNOG; KOG3599; Eukaryota.
DR HOGENOM; CLU_009624_1_0_1; -.
DR InParanoid; A7RJ05; -.
DR OMA; FAENNTH; -.
DR PhylomeDB; A7RJ05; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR PANTHER; PTHR10877:SF150; POLYCYSTIC KIDNEY DISEASE AND RECEPTOR FOR EGG JELLY-RELATED PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF01477; PLAT; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50095; PLAT; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 132..251
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDO48598.1"
SQ SEQUENCE 315 AA; 35759 MW; D739E53CFA3E46C5 CRC64;
MTDVNYTLKV SEASCMYFDK MIGSWSNEGC KVRQSNSSHV HCLCDHLTSF GGDFLVAPNP
IDFDKVFVEF RRMGETGNFV VLTTICSIWG LFIAGIIIAR RADNKDKKKA CNFISFQVVA
NINLVENIIE GFAYQITVQT GMWRDYGTTA NVGLSIFGEK GKVEDILLTD PELEKVLFSR
GSINNFTLVV PEDLGELTKI KIWHDNSGRS PAWFFHQVMI VDMQTEKQYY FLANRWLAVE
KGDGQIDIEI PKAEKKDLSG FRNLFYSRTA KSLGDGHLWL SLFTRPPHNP FTRCQRLGCC
LSILFATMVT NAMFY
//
