ID A7RJE4_NEMVE Unreviewed; 2536 AA.
AC A7RJE4;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Ig-like domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=NEMVEDRAFT_v1g238736 {ECO:0000313|EMBL:EDO48362.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO48362.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO48362.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS469514; EDO48362.1; -; Genomic_DNA.
DR RefSeq; XP_001640425.1; XM_001640375.1.
DR STRING; 45351.A7RJE4; -.
DR EnsemblMetazoa; EDO48362; EDO48362; NEMVEDRAFT_v1g238736.
DR eggNOG; KOG4193; Eukaryota.
DR HOGENOM; CLU_228282_0_0_1; -.
DR InParanoid; A7RJE4; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15040; 7tmB2_Adhesion; 1.
DR CDD; cd11304; Cadherin_repeat; 1.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR010281; DUF885.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR33361:SF2; DUF885 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR33361; GLR0591 PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF05960; DUF885; 2.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13895; Ig_2; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 105..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2168..2190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2202..2220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2232..2250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2270..2297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2319..2343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2364..2383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2395..2417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1640..1721
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2166..2419
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 29..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 198..225
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2536 AA; 284221 MW; 4E6273313FD783EA CRC64;
MSRDHWQVPL NTGTYFGLVA TPIDNRSLNS HSPSEAYSNN KNNNHYYNYQ KVNDDATPES
KNGLSGKPNS TIPVRFSRYS NAKKGLKQST QKSDKLRKCL NVSKVLVPLI LAVVIIIILI
VVPLTLQASK KKQPTEQSQR RKCSLSQELK DSGLYELIQK VRKSVSKNYP ADLVINPAST
SEQLWRDYKP FIAKPEQYKQ VTDEAEGLLG ELEEIRKKID ENKLKGRERK AFYEVQHYLR
NSFGTAFEGN YYTGDWMLEP NGFCWSPSCL SVPYFSTALS WYLKPENIGH VRRLIEIIKQ
FRESILQTIA NMRMGVRAGM VRPLEACRAG FLAYRSQFSP IAIQKEKAGS LIRAASMIFR
FTNKRERNID DARVKDLFIY SGVYEQGFLS MLTPEMHREW LKDNGENITE SITRNLEEHI
GKPILEVLQY LENEHMKYCP PSTVSSGLAL LPLEYVYING VPDYSQRTTQ KLPTGEPLNG
TRSFLWIAQS MVAKHVTPEE LEKLGREQLQ IFYAEAVSIA KQATGESDEA QAIAKFKEII
EDPSNYFNQK PFPANESDDN AFLLCTSDEK AKMYCPKRWE ALQDWTKYVR KLQNNIKAQL
GQIFYTSGPK VTTPTCDNYI FPDYKPAAAF RAYSASWTAN CSAGRAGHVL TFFMDKFGPK
FSDYSLAAHE YQPGHHTEVQ GFFEHFMDKC GDAIAWLTDQ SFFSGFSEGW AMYSEHPLMD
EDLKMYEGNL LARYGMIQQM NMASLRLIIE PGLHVRGMTR SAALQLFQKY TWDTSDLSSK
EITRYQSTYG QGLTYMVGRN AILQARSKAE QELGKEFSIQ DFHYAILHQG DLPLDYLPAH
IDHYIKCRKN PSSSEYALMS HLLKIKIKNW PADFNLKYSD SLALQHSKKM NRALQNNIKA
QLGQIFYTSG PKVTTPTCDN YIFPDYKPAA AFRAYSASWT ANCSAGRAGH VLTFFMDKFG
PKFSDYSLAA HEYQPGHHTE VQGFFEHFMD KCGDAIAWLT DQSFFSGFSE GWAMYSEHPL
MDEDLKMYEG NLLARYGMIQ QMGQDGVGVG LEGPNRIRHG STNGSLLSFW NWNGHHIDFW
HVGCFKDTRT RALPFRVISI ASTEPDTIVR CANVTWTLGY DAFGVQNGGE CWTGVNASGT
YDKYGVLDGA SCGNDGKGGR WANDVYFLNS STGGFEMLRC YEAQASLSYQ NLGLDSVSED
DIRPILSDML VTMSRFLGTR LNTCKAVDLV LGSITMIERT DNLEIHFAII FTTNKSISRD
KVNSTLWRCS SIARQNTVLL MNVKTLEVNN VAHSPKEACL PGYGREKGGC ALCKANQYSE
HQARPCKNCP PGTNTWGRKG VVNKANCTGR NPINVSEKTV TLPFGLKAGE VVAKVTASYI
SGSLVIPPLV YAIRRVTMAT DESSSSKSPK EDDAMDFFSI DDNTGEISIT KKFNFSDGVN
YVADVNVSDS VAPDLGVITR QVKVRFECRD VCKRSRELYQ GVTEVCTETN VTKRINGVNT
TSLTISNLDM TTINSCQLRR ELEEGNYVLW LQSGSQKLRI NFTVQVEEEF SGKPFSIKNF
SITNNELKVG VLSHQGPKSF SDSQGVTIVG IERPNCQSVD FACKSKVLTW RNAVGKNGDE
SCGADPKMML LRYGDCVALP TTSLLITKAP SEDDPSVTLL CTVKSPLSYN ITWYHNNVLI
PDLSLTKPDY SFQVTRERQG NYACVAESIA GMTRSTSVLV APKNMYTWYL LLVSTKKNQP
PNDVASKVQS FLNSYHDQNR YSVLKKGEPT DKGRRMKFVV YETKDGSNVT TAYNRLKENL
VRGASDELKQ LKLKKNNIGV TSAEYCFAEA TGKEDIKGKY NWQTTKLSKV VTLSCFYNHE
ENATRICIGD FASGATWEDP MLERCQYKSK RTRQLHDISQ QPITNANAKS TADELKTLLS
QTPAKDLNEA DASLVADTLD NLVDNKESLN ETGDVIVAVV SDIMKMDKKT LSSSKQASTK
IVKTLDTLVM TMPLPEGQTS KQLTADSLTL QLNQINISAF SGLTFSKKGS SSVQLPITLF
QAGDQYSDRV GFIYYGNNKL FQVDEANVLD DDAEGLVTSD VILSCSVYNT SIRNLSEPVA
LTFPKPSGVW ELKCVYWVDN MSIWSNEGCH VTDNGGCACN HLTSFAMIFS PPGQARDGDD
PLTKSLTIVS YVGCAISLVG VLLTLLTYSL FRHLRKTNQQ PILINLCIAL GLLLVVFLAG
ASRPEPQLGC QIVAVLLHYL TLAVVLWMGV EGYNLYLQIV QVMATYRRRF MLKAVVFAWG
VPAVIVAITA TVAAVLVNKN PGSLFSYGSK TACILYDPLY YWIAWFAPVL LTLTINIVVY
ALVVHKLGCT DAMVNPEKKS VQRYRVRTAL AIMVLLGLTW LFGALSFGDK LQRVTFEYLF
CIFNSLQGLF IFIFHCLRIK EVRNQWKFFF SGFGISHRGT SDSYQRSKGI GESHHSSEAP
YAKVTHYVAR HGSDLQRPRK ETVSTIVAGA NNSVGDTKDF CGENHVDIEL KDNYNTGLEF
NNGEIGHEEI NCDKIV
//