ID A7RKM6_NEMVE Unreviewed; 748 AA.
AC A7RKM6;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDO48013.1};
GN ORFNames=NEMVEDRAFT_v1g238957 {ECO:0000313|EMBL:EDO48013.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO48013.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO48013.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the cornifelin family.
CC {ECO:0000256|ARBA:ARBA00009024}.
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DR EMBL; DS469516; EDO48013.1; -; Genomic_DNA.
DR RefSeq; XP_001640076.1; XM_001640026.1.
DR AlphaFoldDB; A7RKM6; -.
DR EnsemblMetazoa; EDO48013; EDO48013; NEMVEDRAFT_v1g238957.
DR GeneID; 5520230; -.
DR KEGG; nve:5520230; -.
DR eggNOG; ENOG502QRGP; Eukaryota.
DR HOGENOM; CLU_010118_5_0_1; -.
DR InParanoid; A7RKM6; -.
DR OMA; NPFITEG; -.
DR OrthoDB; 2905644at2759; -.
DR PhylomeDB; A7RKM6; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071705; P:nitrogen compound transport; IEA:InterPro.
DR InterPro; IPR000060; BCCT_transptr.
DR InterPro; IPR006461; PLAC_motif_containing.
DR PANTHER; PTHR30047:SF7; HIGH-AFFINITY CHOLINE TRANSPORT PROTEIN; 1.
DR PANTHER; PTHR30047; HIGH-AFFINITY CHOLINE TRANSPORT PROTEIN-RELATED; 1.
DR Pfam; PF02028; BCCT; 1.
DR Pfam; PF04749; PLAC8; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 692..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 83375 MW; 885EF162874557C4 CRC64;
MGEIHTGDMS QIERCRTIKF KIGKMRVNFN PVVTIFSAII IWSLVLFCLV KTDLAAKEMP
TWAKWVTDKW TWLYIGTQDV WAVFILVLFF SKYSNLKLGK TDDEEPEFND GSYFSMLFAA
GIGVGLFYFG VAEPVLHYEP GSKWGNRYQG RYSDNQRAQD AINVTLFHWG IHGWIVYTMI
GLLLGFLSYR YDMPMTMRTC FYPLLGDKIY GTFGDLIDIL SVVCTMFGVC TSLGAGAIQL
NDGLNRLNSA IEESKMNQVI IIWVITALAT VSVISGLKVG IRRLSEICFS VGMFIFLVVF
FYDDTWYLLN VFVQSIGYYL QWIVQIGFHT DAFAQMGNAP DGKEAPEWMS EWTIFYWGWW
IAWAPFVGVF IARISRGRTI KQFITYTLTV PVVYCIMWFS VFGAIGIKME REAINAGIEC
NSTLGGRDSL QSLNGIYRLS CRPSTRMWFD VMEQYEGIGS FMSGLSIVGL VLYFVTSSDS
GSLVIDSLSA NGHPDPPVLQ RVFWALTEGA CATGLLWTGG SKALSALQAA SISSGLFYTV
ILNFVCVAIW RAVKYDTGDL DMSGPLFSMG IFDIFYKPSY KRLRNLVIAM TAPWYLMGKA
AGKVNNGGKR TAMITLGLTF YTAVGLQILH FFRPGTAYLG AALIVGFFVY GAGIRLAVRE
KYAIVGNMVE DFFAVMLLYP LAAMQMDEQL DNSKTSSEST IDSGSSAEDE SAPLGHKTPH
LCIHVNDSGR SSMAGKHLRA CLLLSAPL
//
