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Database: UniProt
Entry: A7RL66_NEMVE
LinkDB: A7RL66_NEMVE
Original site: A7RL66_NEMVE 
ID   A7RL66_NEMVE            Unreviewed;       338 AA.
AC   A7RL66;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   08-MAY-2019, entry version 54.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
DE   Flags: Fragment;
GN   ORFNames=v1g33267 {ECO:0000313|EMBL:EDO47878.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO47878.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J.,
RA   Salamov A., Terry A., Shapiro H., Lindquist E., Kapitonov V.V.,
RA   Jurka J., Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E.,
RA   Finnerty J.R., Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|RuleBase:RU610713}.
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DR   EMBL; DS469517; EDO47878.1; -; Genomic_DNA.
DR   RefSeq; XP_001639941.1; XM_001639891.1.
DR   STRING; 45351.EDO47878; -.
DR   EnsemblMetazoa; EDO47878; EDO47878; NEMVEDRAFT_v1g33267.
DR   GeneID; 5520081; -.
DR   KEGG; nve:NEMVE_v1g33267; -.
DR   eggNOG; ENOG410IECJ; Eukaryota.
DR   eggNOG; ENOG410XPZT; LUCA.
DR   HOGENOM; HOG000015133; -.
DR   InParanoid; A7RL66; -.
DR   OMA; VQIFYDM; -.
DR   OrthoDB; 1096692at2759; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   InterPro; IPR001329; Venom_Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   PRINTS; PR00847; HYALURONDASE.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001593};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT   ACT_SITE    106    106       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   DISULFID     19    302       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    182    191       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    327    338       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:EDO47878.1}.
FT   NON_TER     338    338       {ECO:0000313|EMBL:EDO47878.1}.
SQ   SEQUENCE   338 AA;  38060 MW;  57FF01709E0C1C28 CRC64;
     PALPNRTFIS VWNAPTSACE SRWGININLS SFDIVTNRGQ TFYGESIVLL YSNIGLWPYI
     NDKGDKINGG IPQLGNLSAH LDKALDDLLK VVPDPDFQGI GVIDWEAWRP VFDRNWDSKT
     IYKEASEALV KQQHPDWSSK AIETEARKQF EDTAKDYMLQ TLQLAKKTRH KALWGYYGFP
     RCYNGKGPSD CSGVVKAEND QLSWMFESSS IIFPSIYLSP SLPRNRSSTF AKYSILEAFR
     LAVDEHGSNL PVFPYVRIVY AQTQIFLNKA DMYSTIVQAA KLGTAGVIIW GASSDMENAE
     FCTELYNYIE GFVGPLIKTL SDIAQDCSMQ YCSFHGRC
//
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