ID A7RLS2_NEMVE Unreviewed; 1004 AA.
AC A7RLS2;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Fibronectin type-III domain-containing protein {ECO:0000259|PROSITE:PS50853};
DE Flags: Fragment;
GN ORFNames=NEMVEDRAFT_v1g198971 {ECO:0000313|EMBL:EDO47651.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO47651.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO47651.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
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DR EMBL; DS469518; EDO47651.1; -; Genomic_DNA.
DR RefSeq; XP_001639714.1; XM_001639664.1.
DR AlphaFoldDB; A7RLS2; -.
DR STRING; 45351.A7RLS2; -.
DR EnsemblMetazoa; EDO47651; EDO47651; NEMVEDRAFT_v1g198971.
DR eggNOG; KOG4258; Eukaryota.
DR HOGENOM; CLU_000288_166_0_1; -.
DR InParanoid; A7RLS2; -.
DR OMA; FFILCTC; -.
DR PhylomeDB; A7RLS2; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR PANTHER; PTHR46877; EPH RECEPTOR A5; 1.
DR PANTHER; PTHR46877:SF14; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR SMART; SM00060; FN3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS50853; FN3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1004
FT /note="Fibronectin type-III domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002713615"
FT TRANSMEM 952..978
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 845..937
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 753..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1004
FT /evidence="ECO:0000313|EMBL:EDO47651.1"
SQ SEQUENCE 1004 AA; 111195 MW; 8D890174D819CBCD CRC64;
MKNKGILIGV IWLLKCCLSR PQDHGYELCK PNLTPPFGRV KVHVLKSKGP GNSCQGCAEL
KNCTTFDGAI QIQGYRVSDA NSAKELYFPK LTEITGHLLV SLLFNIKDLK GIFPNLAVIR
GRYLFLDYAL VIYQNNGLEQ INLPSLTTIS SGGIRIEKNI NLCYVKTIRW KSIMKMNSDD
PYSLVTSSNN NDCYDLCYKG ECTVPAGHGA SGKQYCWSSG DPSDFSCLKH YYKLESTCVL
ECPAGYQAKE KIDFIRWEKT KTCEACLTER CPRVCKVSSN QGNGGIIDSI SSLRHYKGCT
DIKGNLEIKL RGGGQTIAKE LEDNLGMIER VTGYIVIRES VAIVTLKFLK NLRLIEPEKT
IDVQKRRLVD VLYNDRYALT IMDNPKLEAL WDFRSDLQIT AGGILVRMNP RLCPGRIDPL
VNDVLQWTNA SLGRPVDVSQ TSNGNAVACQ VKAINMTVRE LVKPMFSACA DVCVEVSWEE
VRIKEDYRNV LFYSISYRVA PDRDITEFDG VDACSATQVW TRIDVPAGDP GTVNTSVSSP
GFRPVNRLSR FIGKLTPHTL YAFYVEAATL NNTGARSALM FLQTREMIPS AVVGLEASYL
DPFTLLVKWQ PPLYPNGNIT KYLVQYQQSE YSVWRQPGID WCIRQVLRDG DSKDGDDGKD
ADKNGECKVN ITCNCDEEKE VDKPEKRAAL FAKEFQDVLF KAIFTKTKDD NPSPTNQTTT
PPTSMTFLVN GTNCTAEDQA NGLCEQISTT ASPTSTASDV TTESTYTTPV SNDSSTTVNT
TMIPTTSIPV LEANGTEGSI RISGLKHFTD YTIQVCACTS AGCATNTRCS NTRGRTHRKE
KADDLTGVVK VHVNNATRSF NISWGQPVDP NGVVLKYDVE VSYASRSSPE IVCWQGHKPS
WLVREGMYGN YSVRVRAITP AGNGSWTSPV LFTIHEEKDP GGSGKLVQSS RVGVIVGSSL
AACSVFILTC GIVIWFVVRK RYQEKQVPTV LYASVNPEYM NSTD
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