ID A7RM77_NEMVE Unreviewed; 649 AA.
AC A7RM77;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN ORFNames=NEMVEDRAFT_v1g86565 {ECO:0000313|EMBL:EDO47553.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO47553.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO47553.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS469519; EDO47553.1; -; Genomic_DNA.
DR RefSeq; XP_001639616.1; XM_001639566.1.
DR AlphaFoldDB; A7RM77; -.
DR SMR; A7RM77; -.
DR STRING; 45351.A7RM77; -.
DR EnsemblMetazoa; EDO47553; EDO47553; NEMVEDRAFT_v1g86565.
DR eggNOG; KOG1055; Eukaryota.
DR HOGENOM; CLU_005240_3_1_1; -.
DR InParanoid; A7RM77; -.
DR OMA; VACIHES; -.
DR PhylomeDB; A7RM77; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IBA:GO_Central.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IBA:GO_Central.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IBA:GO_Central.
DR CDD; cd15047; 7tmC_GABA-B-like; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 426..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 426..649
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDO47553.1"
SQ SEQUENCE 649 AA; 72842 MW; E6E16D1572C73407 CRC64;
MKSSANVPLY IGGFIDLNTT NGGWNSGGVY PAIELALQHI NQDQSLLQGI KLELVIKDSR
CSDAYAIKTL VEHITADHTV VMLIGPGCSI AAEPIAIAGK FWNLVQVAYA AGTPRLSDKT
LFPLFYRVNA PETVANLAIV AMLKKFKWSR VAIVKEDVAV FNDVSEGLQL LLRRENISLI
GANSFITNPD NVITDLKQKD ARIIIVLTYE GKCRKLMCSA FRHGFYGKHI VWLLRGWYVE
DWSKVVTDVT CSPQEVQSAH GNYIAFEEVI LSTSTEKTIN GLTPDQLNKL YLRQARNISY
PINSYAAYGY DAMWVVALAL NRTNTLLKES GLTLHNFTYD NKYIASIINE STAKTRFFGM
SGEVAFLDNG DRISSMWIEQ FQDDGEIRVG VFDATHGDTG VDRINGSPPP SEPVTITEIV
LIEMPLFVTM ATIACAGIFL STLFLILNIK NRQRTFIRMS SPYLNNFIIA GSIMCYTCVI
LFGVDVFLDE SDHVIHSAIC SFRLWLLSCG YTLAFGTMFI KTWRVYKIFT NHKLDKQLGR
LHDRHLVCML ALMLSVDLLF LSVWQAVDGL KTEIRNVQTE NGRNKITILM PVFLACTCTH
KLIWLGCLYT YKGLLMIFGL FLAWETRNVS YPALNDSRYI GLSVYNVVI
//
