ID A7RN03_NEMVE Unreviewed; 182 AA.
AC A7RN03;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 67.
DE RecName: Full=Calcium load-activated calcium channel {ECO:0000256|PIRNR:PIRNR023322};
DE Short=CLAC channel {ECO:0000256|PIRNR:PIRNR023322};
GN ORFNames=NEMVEDRAFT_v1g179997 {ECO:0000313|EMBL:EDO47188.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO47188.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO47188.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- FUNCTION: Calcium-selective channel required to prevent calcium stores
CC from overfilling. {ECO:0000256|PIRNR:PIRNR023322}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMCO1 family.
CC {ECO:0000256|ARBA:ARBA00006537, ECO:0000256|PIRNR:PIRNR023322}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS469521; EDO47188.1; -; Genomic_DNA.
DR RefSeq; XP_001639251.1; XM_001639201.1.
DR AlphaFoldDB; A7RN03; -.
DR STRING; 45351.A7RN03; -.
DR EnsemblMetazoa; EDO47188; EDO47188; NEMVEDRAFT_v1g179997.
DR GeneID; 5519359; -.
DR KEGG; nve:5519359; -.
DR eggNOG; KOG3312; Eukaryota.
DR HOGENOM; CLU_081121_0_0_1; -.
DR InParanoid; A7RN03; -.
DR OMA; GMFGDFK; -.
DR OrthoDB; 313692at2759; -.
DR PhylomeDB; A7RN03; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IBA:GO_Central.
DR GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
DR InterPro; IPR002809; EMC3/TMCO1.
DR InterPro; IPR008559; TMCO1.
DR PANTHER; PTHR20917:SF0; CALCIUM LOAD-ACTIVATED CALCIUM CHANNEL; 1.
DR PANTHER; PTHR20917; PNAS-RELATED; 1.
DR Pfam; PF01956; EMC3_TMCO1; 1.
DR PIRSF; PIRSF023322; DUF841_euk; 1.
DR SMART; SM01415; DUF106; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRNR:PIRNR023322};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|PIRNR:PIRNR023322};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR023322};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|PIRNR:PIRNR023322};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR023322};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR023322}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..182
FT /note="Calcium load-activated calcium channel"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002711923"
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 30..87
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 182 AA; 20548 MW; B1EAFC4D2ED99664 CRC64;
MFADSLLILF ISLATALLSE GITYILVYRT DKYKKLKAEV EKDSKKLERR KENLTDAPRQ
GGQKKKIERV EEKLKNHNRD LSMVKMKSIF AIGFTFTALI GMFNSIFDGR VVAKLPFEPH
SWIQGLSHRN LMGDDFTECS FIFLYILCTM AVRQNVQKAL GFAPSRAASK VGGLLTPPQA
AK
//
