ID   A7RN86_NEMVE            Unreviewed;       924 AA.
AC   A7RN86;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE            EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN   ORFNames=NEMVEDRAFT_v1g199611 {ECO:0000313|EMBL:EDO47093.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO47093.1, ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO47093.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC         EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
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DR   EMBL; DS469522; EDO47093.1; -; Genomic_DNA.
DR   RefSeq; XP_001639156.1; XM_001639106.1.
DR   AlphaFoldDB; A7RN86; -.
DR   STRING; 45351.A7RN86; -.
DR   EnsemblMetazoa; EDO47093; EDO47093; NEMVEDRAFT_v1g199611.
DR   GeneID; 5519242; -.
DR   KEGG; nve:5519242; -.
DR   eggNOG; KOG1812; Eukaryota.
DR   HOGENOM; CLU_316010_0_0_1; -.
DR   InParanoid; A7RN86; -.
DR   OMA; INCILAR; -.
DR   OrthoDB; 2963174at2759; -.
DR   PhylomeDB; A7RN86; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IBA:GO_Central.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   CDD; cd20336; Rcat_RBR; 1.
DR   CDD; cd16773; RING-HC_RBR_TRIAD1; 1.
DR   Gene3D; 1.20.120.1750; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR031127; E3_UB_ligase_RBR.
DR   InterPro; IPR002867; IBR_dom.
DR   InterPro; IPR044066; TRIAD_supradom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR11685:SF457; TRANSLATION TERMINATION INHIBITOR PROTEIN ITT1; 1.
DR   Pfam; PF01485; IBR; 2.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00647; IBR; 2.
DR   SUPFAM; SSF57850; RING/U-box; 3.
DR   PROSITE; PS51873; TRIAD; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          542..754
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51873"
FT   DOMAIN          546..591
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
SQ   SEQUENCE   924 AA;  105377 MW;  828ED6C4309A97D7 CRC64;
     MGWNERGKYG IHHGRTLRYN ERLPYFLGSN TPSEFLMKHS GDKRGFSDPK AASFLNEAYG
     IDDGLDIVCG LVVPNASFER IHPIPLYSLG KRKRWLLPEL VKERMMESPN DNEDDSDEEE
     LGVCITERHV HFSHSLDCNC LSVATGKGKR GNVFKPKKTY STKRDLNRGG VGDRLLCYEV
     CSATPSQSWP NYIERKFYKR WDMELGRNRD KASCKVRKNK GNRWGGYSER EIRGMAGDSG
     YCSFKKKTRK QKCKEQKGIM RKKTFDLFTK RMHTPKQDRH ATKFDLGSYI ESVLNSKNID
     NEADGQFLED ETPKRKSFKP YEKGCAIYME TKGKSELVPA QSKPEFYEPE LKTSAVINIR
     TQDLDPSRLQ ETWSELYTEG GSFPRKFVID VKPLLSKELQ GDRICKVLFE TEVGPNKDHN
     SSSVITSIVT GSLDTLDDVN NNIKTDFVST LALQKYQEGM ELEDVIKIVV ASASRLLPSC
     KAAIRGSKCD SKSLQSLDIF NELHGWKYKV FSVSEANEKL QQDLVKQAKI RSGIDTRDWF
     MVSKECGICF GDFRENKMTA LMSCGHSFCT ECWEFYLKSQ ISRGEGDIGC PGYNCDVTLD
     NVTIMSLTPS WYPKFLKRKL NRALEMTSSW RWCPGKNCRQ VVNGTELSPN SSAWSVLCKC
     GGIWCFKCGS QAHWPASCVE ARKFYRIAGN YEKLLINERK ELINSVMVKN CPSCHYPIEK
     HLGCNFMTCV MCKTNFCWIC LIDFKDHDRC LKEQSLKEVE LTNEGTTTAR FEGFLEIVRR
     NTFYRLPKNI GGKVKRLKLL AAGVNSYKHI APIINPPCRN PIEIEKLMEK IIANNVLKVM
     EEGLQFSYQA HLAVEGAAKK AAVCKNKGAS VVHSMSQLEF IADRIDELCI QPIELCEKDK
     RAWLSRLIQL GKGYMCNMVK VCEK
//