ID   A7RNS0_NEMVE            Unreviewed;      1061 AA.
AC   A7RNS0;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   24-JAN-2024, entry version 76.
DE   RecName: Full=MIF4G domain-containing protein {ECO:0000259|SMART:SM00543};
GN   ORFNames=NEMVEDRAFT_v1g88040 {ECO:0000313|EMBL:EDO46900.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO46900.1, ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO46900.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; DS469523; EDO46900.1; -; Genomic_DNA.
DR   RefSeq; XP_001638963.1; XM_001638913.1.
DR   AlphaFoldDB; A7RNS0; -.
DR   STRING; 45351.A7RNS0; -.
DR   EnsemblMetazoa; EDO46900; EDO46900; NEMVEDRAFT_v1g88040.
DR   eggNOG; KOG2051; Eukaryota.
DR   HOGENOM; CLU_002633_2_0_1; -.
DR   InParanoid; A7RNS0; -.
DR   OMA; DFQHHQI; -.
DR   PhylomeDB; A7RNS0; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0035145; C:exon-exon junction complex; IBA:GO_Central.
DR   GO; GO:0005844; C:polysome; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IBA:GO_Central.
DR   Gene3D; 1.25.40.180; -; 3.
DR   Gene3D; 4.10.80.160; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   InterPro; IPR039762; Nmd2/UPF2.
DR   InterPro; IPR007193; Upf2/Nmd2_C.
DR   PANTHER; PTHR12839; NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2; 1.
DR   PANTHER; PTHR12839:SF7; REGULATOR OF NONSENSE TRANSCRIPTS 2; 1.
DR   Pfam; PF02854; MIF4G; 3.
DR   Pfam; PF04050; Upf2; 1.
DR   SMART; SM00543; MIF4G; 3.
DR   SUPFAM; SSF48371; ARM repeat; 3.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT   DOMAIN          11..213
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000259|SMART:SM00543"
FT   DOMAIN          414..603
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000259|SMART:SM00543"
FT   DOMAIN          618..831
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000259|SMART:SM00543"
FT   REGION          333..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          845..900
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        337..355
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        851..873
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        886..900
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EDO46900.1"
SQ   SEQUENCE   1061 AA;  122487 MW;  F1C3BCD3C7203CF7 CRC64;
     ENLMKGLDSS VKKNSSFTKK LRSITEPQRD ALTTEFNGLN LSRYIQEAVS IELCLETNQA
     DVSCVAHICS LFHQRYQEFS DLLKKELVKV FENYAGKDED RAANVTRYRV TLRLLGELIL
     YGVFENLNEN IKLLGGILNN IANCDKESHI YVQVIISFAK HCGEDFAGVL SRKHRALVEK
     HNITWPYTGI IPRDAQASFR HLLQSYYKTL AKHLLQVHKD LQNRERQNRQ ILLTKGELHA
     DKKESLERAQ KSYEKLLAST SNLADVLDED MPDLPQDELI QQCEGSSTVD IFNPFKNQEY
     DGESGIWEDE DYRVFYENLK DLKASLPGIL YKEDPRTGSS ESLDSVDEKV TDKDSSIGNQ
     VELLDDADEE LNIEEDFADS DKEAEDTIFC YFFTGADESS ESASVVTSGA AAMEALIAKL
     PTCVNKDMID EVAMDFMLSC NNKKNRKKLT RAVLTVQRTR LDLLPMYSRL IATLDQCVSD
     ISPEVVKALK GEFRFHVRKK DQINLESKIK SVRFIGELTK FQIFPKGDAL HCLKMLLEDF
     SHHNIEMACN LLEVCGRFLY RSPDSHIRTK NLLEVMMRKK AVQNLDGRQL TMVDNAFYYC
     NPPERQKMMQ KVRPPMHQYI RKLLYKDLSK TTTERVLRQI RKLPWDNTEI ALYAIKCFIR
     IWNVKYNSIH CAANLLSGLS AYHEELALFI VDGVLEEIRL GMEVNHPKLN QRRVCCVRYL
     GELYNYRLVE SRVIFNTLYS FLTFGNPDDG SSSELDPPQH LFRIRLICTL LDTCGQYFDH
     GNYRKKLDCF LVYFQLYINR KKSSPEWNES RPFPRDVDYM IADTLEILRP KLTVCSTLQE
     AQEQVEQLER DQKQQIGNSS HGSPHTSITG SPCPSPMPRD DYEPSESGES EQDDSEVLDV
     DDEYEMIDME MDDDETAMHR VTRGRFLMKY LYINPSTPPK KVEPTAEDQE FQQMFERLMV
     DDLHSRRGES LKVPSLDVAV PMHLKGQVRK AEGAVDEKMN FVLMLRKGNK QQYRDLEIPI
     SSDLAANMRE KQVAEQAEQQ ELKRLVLDHN QRQEEEIYNG E
//