ID A7RP85_NEMVE Unreviewed; 655 AA.
AC A7RP85;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
GN ORFNames=NEMVEDRAFT_v1g239725 {ECO:0000313|EMBL:EDO46692.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO46692.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO46692.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family.
CC {ECO:0000256|ARBA:ARBA00005241}.
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DR EMBL; DS469525; EDO46692.1; -; Genomic_DNA.
DR RefSeq; XP_001638755.1; XM_001638705.1.
DR AlphaFoldDB; A7RP85; -.
DR EnsemblMetazoa; EDO46692; EDO46692; NEMVEDRAFT_v1g239725.
DR eggNOG; KOG3762; Eukaryota.
DR HOGENOM; CLU_013133_2_1_1; -.
DR InParanoid; A7RP85; -.
DR PhylomeDB; A7RP85; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17335; MFS_MFSD6; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR024989; MFS_assoc_dom.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR16172:SF2; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6; 1.
DR PANTHER; PTHR16172; UNCHARACTERIZED; 1.
DR Pfam; PF12832; MFS_1_like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 573..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 444..655
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 655 AA; 73818 MW; E38A00BA8EA65FB2 CRC64;
MIPCSYKRIE DESLPDNKGV KSREKLFLTL QDIDRGFIIS KLFYFLFYSS LGALFPFLSL
YYKQLWLSPI QIGILLALRP SVKLVCLPLW KMVTDKFSKY KFVYFISMFG WIIGYLGQTF
VCPVQLPCYV ENPLTTQVAI PTTYLAPFNQ SGKLLNLSTR NVTSINSWNG NDMKLIKRDR
SDRYTVLPYE KFSTTDGELS AKDNEFLSRS LAKGPGPASL IVHRKLIKES EMSKKPTVGH
QKEAGYHKAS EREFLGEKRL LFERKKGAEK QLLQKRNENY ATIEPLVLKS SSTHFSKSKS
TLTKSKSKTS PHPSHDFRVH YNSLIFLTLL VIVFLTEVLT TPTLMLADSE VVQALANTES
RYGDQRLLGS FGLALAALLA ALWTTLWSEC HYTDTINYLP CFYLFEIALA ATIIISLFFK
LDSPDIEGNE VNIFDGLKFF KTPRAGFFLL TIFLLGFAHS IQISFLFWFL QDLGGTPILF
AVIIIVYSFA EVVMYFSSSF VVQKIGHQGT LSLALACYTA RFLMYANLTD PWLVIPIELV
QGLTYGGVWS IAPTYISVPE EASSMIQNIL QGAYWGVGMA AGSLISGVVI QAYGVQTEFS
VVAVIAFALF TVHVSLVISD RVKAIDEELA QRKQEGLDNL LAVLFKLRVN FCRLL
//
