ID A7RPR3_NEMVE Unreviewed; 475 AA.
AC A7RPR3;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Unspecific monooxygenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=NEMVEDRAFT_v1g200272 {ECO:0000313|EMBL:EDO46618.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO46618.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO46618.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617}.
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DR EMBL; DS469526; EDO46618.1; -; Genomic_DNA.
DR RefSeq; XP_001638681.1; XM_001638631.1.
DR AlphaFoldDB; A7RPR3; -.
DR STRING; 45351.A7RPR3; -.
DR EnsemblMetazoa; EDO46618; EDO46618; NEMVEDRAFT_v1g200272.
DR GeneID; 5518736; -.
DR KEGG; nve:5518736; -.
DR eggNOG; KOG0156; Eukaryota.
DR HOGENOM; CLU_001570_22_0_1; -.
DR InParanoid; A7RPR3; -.
DR OMA; YMIPATH; -.
DR OrthoDB; 2900138at2759; -.
DR PhylomeDB; A7RPR3; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0047442; F:17-alpha-hydroxyprogesterone aldolase activity; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004508; F:steroid 17-alpha-monooxygenase activity; IBA:GO_Central.
DR GO; GO:0042446; P:hormone biosynthetic process; IBA:GO_Central.
DR GO; GO:0042448; P:progesterone metabolic process; IBA:GO_Central.
DR CDD; cd11027; CYP17A1-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24289; STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE; 1.
DR PANTHER; PTHR24289:SF1; UNSPECIFIC MONOOXYGENASE; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
SQ SEQUENCE 475 AA; 54290 MW; 78A0AC7582F89982 CRC64;
MRKKQDANLP PGPPPLPLLG NMLDIWGSMP NIHLGFSKLA KHYGDIYTLY LQGNRVVVVG
SAAIAREALV LRKDDFSGRP YSFIGDFFTR GCKDLAMADL SPTLKWQRKL VHTALRLYSP
RLEGQVCEEV DGLIKRLKAA NGNPIDPKHD LFLTILNVIC NMVFGSCYSM NDPEFLQVVH
YNQLGFRLLS PVSLVNIFPW LLKLPTQQAR DFYYVRDVQG KILDQKFSQH KATFNSSNIR
DFTDALLKAR LEAVQENEAV HHMITEDHLI MTIADVFSAG AETMTTTLRW FIACLVNFPD
VQKKIQNELD CVVGRHRLPT LEDRERLDYL EAVITEVHRY CTVTHLSLPH KATCDSHLHG
YSIPKDTVIM FNVWQMHHDE RYWDQPYRFD PTRFLDAKGK LVDVAGIKSF LPFSAGRRVC
SGESLAKKEL FLVTSRLLHQ LTFTSPPGYP VPDLEGEVGM NHFPRPFEVC VNERY
//
