ID A7RQ05_NEMVE Unreviewed; 1083 AA.
AC A7RQ05;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Retinoblastoma-like protein 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=NEMVEDRAFT_v1g239885 {ECO:0000313|EMBL:EDO46411.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO46411.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO46411.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR EMBL; DS469527; EDO46411.1; -; Genomic_DNA.
DR RefSeq; XP_001638474.1; XM_001638424.1.
DR AlphaFoldDB; A7RQ05; -.
DR STRING; 45351.A7RQ05; -.
DR EnsemblMetazoa; EDO46411; EDO46411; NEMVEDRAFT_v1g239885.
DR GeneID; 5518535; -.
DR KEGG; nve:5518535; -.
DR eggNOG; KOG1010; Eukaryota.
DR HOGENOM; CLU_008943_0_1_1; -.
DR InParanoid; A7RQ05; -.
DR OMA; MHWLACA; -.
DR OrthoDB; 519973at2759; -.
DR PhylomeDB; A7RQ05; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0051172; P:negative regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00043; CYCLIN_SF; 1.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 3.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742:SF36; RE32990P-RELATED; 1.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 65..208
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 385..582
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 804..956
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 963..1083
FT /note="Retinoblastoma-associated protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01369"
FT REGION 890..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 969..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1049..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1057..1072
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1083 AA; 120815 MW; EC3FE5DE89EE7BF8 CRC64;
MASSNEDEDT ITKERFDNVC SELNMDEETA ESAWSSYETI RTNYTLEGDS LHWLACALYV
ACRRSVVPTV DSSGTVEGNC VSLTRLLRAS KLSLIQFFSK MKKWLDMSNA SSEFRKKIEH
LERNFQVSTV IFNKYRPIFL DLFKNPSEDT PKAQRSRKSR KQPCSISDVF SFCWTLYVEA
KGNFPAISDD LVNSYHLLLC CLDLMYSNAL AARHRRDLIN TEFEGLPSDF NTRDVRGPSD
APCIVDVLCT KYQGIVLEAK SIKEHYWKPF VQKLFEKRVL RGHEESLSGI LDLGNFEANW
KAINKEYEEY VLSAGDFDER IFLGEEAHIE IGTPAKLFGS SEVDECQKSG LKKNLQEHFS
KTRSLAPQTP LTGRRYLKEK DPCITPVSTA TQSVSRLQAM CSGLKPTPSE RLLTIFKECS
RDPLQSIIDR VENLGEIFLK EYVQPSAERP NSPCSTREFA LRRLKLAEIL YYKVLENITL
SEKRRLQGHL DLTTLLEQDV FHRSLLACCL EIVIFSYNSQ RTFPWVISIL GLAPYYFYKV
IESLIKAEDG LSRDVVKHLN HIEEQVLESL AWSGDSPLWM TIEQAGGVPS CEDVTIPNHV
EAAHPNQNLL ASPIMHPRLQ RICGEEGMPR RIMSPTSPTL QDHFGSPGAS GARRNLMANF
GGAPARTVAM ATASNGHFTR SAGAAQAASN STASVSQVHP GTTPTLLITQ APASGGGFVV
NGIAQAVVLP SSTATTVQVS LSPRSGSTLA TSVIPPGSPV RSPVRLTPQA AVATSHSAST
TPAKPKKTGS LALFFRKVYH MASVRLRDLC ARLDVNEELR GKMWTCFEHS LMHLPEIAKD
RHLDQILMCC VYVMGKVTNS ELSFQNIMKC YRTQPQAASH VYRSVMIKNR RRAPIPNTGS
ESSRGDSGST RTSPIRSTST IPSTPPPPGG SSSTENSPVL ETERGDLIEF YNKVFIKTIK
NFALKFSSSD RSLESPPLSP LPIVRNQGHS PRRQVSARHP VYISPHKNGV PMTPTTRMLY
CFSESPAKNL RDINHMLRQG ENRKRALLQD DIGAPQAKRS TSEEHLQRRL TSMIEERQAN
ASR
//
