ID A7RQV7_NEMVE Unreviewed; 495 AA.
AC A7RQV7;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=procollagen-proline 4-dioxygenase {ECO:0000256|ARBA:ARBA00012269};
DE EC=1.14.11.2 {ECO:0000256|ARBA:ARBA00012269};
GN ORFNames=NEMVEDRAFT_v1g240032 {ECO:0000313|EMBL:EDO46235.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO46235.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO46235.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- FUNCTION: Catalyzes the post-translational formation of 4-
CC hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other
CC proteins. {ECO:0000256|ARBA:ARBA00002035}.
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000256|ARBA:ARBA00004319}.
CC -!- SIMILARITY: Belongs to the P4HA family.
CC {ECO:0000256|ARBA:ARBA00006511}.
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DR EMBL; DS469529; EDO46235.1; -; Genomic_DNA.
DR RefSeq; XP_001638298.1; XM_001638248.1.
DR AlphaFoldDB; A7RQV7; -.
DR STRING; 45351.A7RQV7; -.
DR EnsemblMetazoa; EDO46235; EDO46235; NEMVEDRAFT_v1g240032.
DR eggNOG; KOG1591; Eukaryota.
DR HOGENOM; CLU_024155_1_1_1; -.
DR InParanoid; A7RQV7; -.
DR OMA; HELYAFE; -.
DR PhylomeDB; A7RQV7; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR GO; GO:0004656; F:procollagen-proline 4-dioxygenase activity; IBA:GO_Central.
DR Gene3D; 6.10.140.1460; -; 1.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR045054; P4HA-like.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR InterPro; IPR013547; Pro_4_hyd_alph_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10869:SF207; P4HA_N DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10869; PROLYL 4-HYDROXYLASE ALPHA SUBUNIT; 1.
DR Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR Pfam; PF08336; P4Ha_N; 1.
DR SMART; SM00702; P4Hc; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 3: Inferred from homology;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 372..480
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
SQ SEQUENCE 495 AA; 56619 MW; C27817EBB5EE66D4 CRC64;
MAEVYSALSH TQRIRDIELE LNDALQDYIE EQETRLAAIK RFATEVKHSV DLSAEGSPGS
YIGHPVNMYL MIKRFVNEWP QVEKVVEEQS NSEAFLLDRL ASSKSKFPTS EDLTGAITAI
KRLQEVYALK PVDFSEGRFG FKPKTGYLLG PKDTYKIGRE SYLDGDMVGT AEWMTETLRL
MDLGVSNGAQ APRRTDVLDH LAFAEFKNGD GRKALNHTLE LIKIDPENTR AKNNLAFFTQ
EMKRDENPEN TRAKNNLAFF TQEMKRDESK FTKKEEEKKN VPSYKWMKSR LSQDVFENFN
WHVERDIYKR LCRGEKLPTL NRATVHNPIT GHLETAHYRI SKNCWLSGRE HGEVIDRVER
RIAAMTRLNL ETAEGFQVQN YGLAGQYDPH FDFSRDLANS SLGSLGTGNR IATVLVWMSQ
VESGGATVFP YVGARILPQK GDAVFWHNLL RSGDGDFRTR HAGCPVLSGI KWVANKWIHE
YGNEFHRPCS LRRDE
//