ID A7RY83_NEMVE Unreviewed; 524 AA.
AC A7RY83;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE RecName: Full=Solute carrier family 40 member {ECO:0000256|RuleBase:RU365065};
DE Flags: Fragment;
GN ORFNames=NEMVEDRAFT_v1g97531 {ECO:0000313|EMBL:EDO43654.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO43654.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO43654.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- FUNCTION: May be involved in iron transport and iron homeostasis.
CC {ECO:0000256|RuleBase:RU365065}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU365065}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365065}.
CC -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC subfamily. {ECO:0000256|ARBA:ARBA00006279,
CC ECO:0000256|RuleBase:RU365065}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU365065}.
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DR EMBL; DS469552; EDO43654.1; -; Genomic_DNA.
DR RefSeq; XP_001635717.1; XM_001635667.1.
DR AlphaFoldDB; A7RY83; -.
DR STRING; 45351.A7RY83; -.
DR EnsemblMetazoa; EDO43654; EDO43654; NEMVEDRAFT_v1g97531.
DR eggNOG; KOG2601; Eukaryota.
DR HOGENOM; CLU_020370_1_1_1; -.
DR InParanoid; A7RY83; -.
DR OMA; YPVFISY; -.
DR PhylomeDB; A7RY83; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR CDD; cd17480; MFS_SLC40A1_like; 1.
DR InterPro; IPR009716; Ferroportin-1.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11660; SOLUTE CARRIER FAMILY 40 MEMBER; 1.
DR PANTHER; PTHR11660:SF57; SOLUTE CARRIER FAMILY 40 PROTEIN; 1.
DR Pfam; PF06963; FPN1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|RuleBase:RU365065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365065};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365065};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365065};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365065}.
FT TRANSMEM 25..46
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 58..79
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 162..184
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 281..303
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 341..362
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 443..464
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT REGION 228..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDO43654.1"
FT NON_TER 524
FT /evidence="ECO:0000313|EMBL:EDO43654.1"
SQ SEQUENCE 524 AA; 56887 MW; 65FA203238C1238B CRC64;
GDRMWEFAVA LYLVELTPGS LRLTAIFQLT RTLCTILLGP YVGAWVDANP RLKVAQRSLV
AQNLAVAASA LILLLILSVK LFHGLFVLLV GLAIFVACFS VLAGIATKIA VQKDWVVVIC
QGDKSLLAGT NAIMRRIDLV CKILAPALVG QVMTYVSKSA GVILIASWNV LSVFVEYFML
LRVYHSVPSL AHKKIDKKLT QQENPQESQE EIRGSRDRLV FMETEGGDSE ALVSRPGSAL
PQSPQTSRPK PGIIQRLKTR ITTTKSVWQV YMRQEVARPG VALAILYFTV ISFGSVTTGY
LYTQNLSESL LSILRGVGAL FGIAATFVFP KLRDSIGLVR SGLFSMSAQF ICVLLCLGAV
LAPGSPFDLE TTDFVSITPH LYTSATKLPT DATIASSTFA AIFTPSPTIL ASATLSSLHP
SNSSFPNNCT SYTKHTVVKS YNFSYVSVIL LLSGIITSRF GLWLTDLTVT QLQQEIVAEE
ERGRVGAVQK SLCSMLDMAI YVLVISLPLP EQFGYMAIIS VAAV
//
