ID A7S0A5_NEMVE Unreviewed; 969 AA.
AC A7S0A5;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Latrophilin Cirl {ECO:0000256|ARBA:ARBA00015543};
GN ORFNames=NEMVEDRAFT_v1g204814 {ECO:0000313|EMBL:EDO42800.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO42800.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO42800.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBUNIT: Forms a heterodimer, consisting of a large extracellular
CC region non-covalently linked to a seven-transmembrane moiety.
CC {ECO:0000256|ARBA:ARBA00011834}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS469560; EDO42800.1; -; Genomic_DNA.
DR RefSeq; XP_001634863.1; XM_001634813.1.
DR AlphaFoldDB; A7S0A5; -.
DR STRING; 45351.A7S0A5; -.
DR MEROPS; P02.013; -.
DR EnsemblMetazoa; EDO42800; EDO42800; NEMVEDRAFT_v1g204814.
DR eggNOG; KOG0621; Eukaryota.
DR eggNOG; KOG4193; Eukaryota.
DR HOGENOM; CLU_305952_0_0_1; -.
DR InParanoid; A7S0A5; -.
DR PhylomeDB; A7S0A5; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15933; 7tmB2_GPR133-like_Adhesion_V; 1.
DR CDD; cd00037; CLECT; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF347; LATROPHILIN CIRL; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 445..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 639..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..158
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 442..688
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 969 AA; 107518 MW; E52E2A9EF2338A2D CRC64;
MELSAGERAC ISRNPHWLKV ILPVMSPRAF RLTPLFFQAL LLCLTSDGQL TLSQGSANWS
SALQSCRLEG KQLAVLDTDN KIHEARNLAG GMKAWIGLRY GGDQRGILLW SDGSDAQSIK
NKCVGSFANN KSCYHLHSGG GKPFKDEHCT EKLRYMCQVV NGSSLPTIAT SSNRVGTSSL
KETPVLSSVT IATSSYSLLK SSRPAVISPS HSRTVTATTT ASVRPSNRIE SMLMRFRHMT
SQLNLTNSES IKALVTSFGA TISNLSDLDL VISNRKNASA NLMSVAKEME SFSMRYARIH
LRGERETFSI TSANIGGNDS IVVNLFYNVT LELRRTLLQN KEVPLVNTHI ISSSIFPKRD
YREPVMLTFR HLKAVENGSQ TSCQFWNFSL SDHGDWSDNG CYVIKSSSTH TTCACHHLTN
FAVLMRLTPT SMMMGSEHRI ALSSISYIGL ILSLLGEAIT VAAYLSFLNV RKDRIQIRLN
LIVNLMLAQI VLIAGLNVTG HKTLCLVVVA LVQFTYTASF CWMLVEGCYL YRVIVKVFNY
HIDLRYCYAI SYGFPTLMVV AALLYAYLLT GEIQGYVSTN VCWMNYDNHV IWMFAGPVIF
IATVNMLVLG CVVKEMILLP TVDPENSRTS ENIRSSARAI VVLTPLLGIT WLFGLLSLSG
IGVVGDYIFT ILNSSQGFMI FIFHCVRNSE LKAAFNLRVY QLESSNLHVN LRSPTPSPAI
LTHMRSGNQG SSTDVVQGVT KVITRDSSCV TNTNLRDGHH VTKSLGEITA DINQEDADEV
SSNMTDTSGS GVYKTCRLTI VSRIVSRIVS RIVSRIVSRI VSRIVSRIVS RIVSRIVSRI
VSRIVSRIVS RIVSRIVSRI VSRIVSRIVS RIVSRIVSRI VSRIVSRIVS RIVSRIVSRI
VSRIVSRIVS RIVSRIVSRI VSRIVSRIVS RIVSRIVSRI VSRIVSRIVS RIVSRIVSRI
VSRIVSRIV
//
