ID A7S0J1_NEMVE Unreviewed; 1157 AA.
AC A7S0J1;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE RecName: Full=DNA damage-binding protein 1 {ECO:0000256|ARBA:ARBA00014577, ECO:0000256|RuleBase:RU368023};
DE AltName: Full=Damage-specific DNA-binding protein 1 {ECO:0000256|ARBA:ARBA00031668, ECO:0000256|RuleBase:RU368023};
GN ORFNames=NEMVEDRAFT_v1g241997 {ECO:0000313|EMBL:EDO42742.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO42742.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO42742.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- FUNCTION: Component of complexes involved in DNA repair and protein
CC ubiquitination. May play a role in the regulation of the circadian
CC clock. {ECO:0000256|RuleBase:RU368023}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|RuleBase:RU368023}.
CC -!- SUBUNIT: Component of the UV-DDB complex.
CC {ECO:0000256|RuleBase:RU368023}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU368023}.
CC -!- DOMAIN: The core of the protein consists of three WD40 beta-propeller
CC domains. {ECO:0000256|RuleBase:RU368023}.
CC -!- SIMILARITY: Belongs to the DDB1 family. {ECO:0000256|ARBA:ARBA00007453,
CC ECO:0000256|RuleBase:RU368023}.
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DR EMBL; DS469561; EDO42742.1; -; Genomic_DNA.
DR RefSeq; XP_001634805.1; XM_001634755.1.
DR AlphaFoldDB; A7S0J1; -.
DR STRING; 45351.A7S0J1; -.
DR EnsemblMetazoa; EDO42742; EDO42742; NEMVEDRAFT_v1g241997.
DR eggNOG; KOG1897; Eukaryota.
DR HOGENOM; CLU_002893_0_1_1; -.
DR InParanoid; A7S0J1; -.
DR OMA; HQDFLMR; -.
DR PhylomeDB; A7S0J1; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.150.910; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR10644:SF3; DNA DAMAGE-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR10644; DNA REPAIR/RNA PROCESSING CPSF FAMILY; 1.
DR Pfam; PF03178; CPSF_A; 1.
DR Pfam; PF10433; MMS1_N; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU368023};
KW DNA repair {ECO:0000256|RuleBase:RU368023};
KW Nucleus {ECO:0000256|RuleBase:RU368023};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 75..552
FT /note="Cleavage/polyadenylation specificity factor A
FT subunit N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10433"
FT DOMAIN 803..1117
FT /note="Cleavage/polyadenylation specificity factor A
FT subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03178"
FT REGION 765..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1157 AA; 127514 MW; 9C92A432B940D3C0 CRC64;
MTHNYVVTAQ KPTAVNAAVV GNFTGPDDLN LVIAKNTRLE IHLVTPEGLR PMLDVGLYGS
VGVMELFRPP NEPQDLLFIL TAKYRVCILG YRKETGDIVT RACGDVQDRI GRPSDTGQIG
IIDPSCRVIG LRLYDGLFKV IPLELDSDKE LKAFNIRLEE LHVVDIQFLY GCANPTIVFI
YQDPHGRHVK TYEINLRDHE FAKGPWKQDN VEVEACRVIA VPNPLGGALI IGQESITYHK
GSNYHAIAPP ALKQSSLTCH GKIDTNGSRY LLGDMNGRLY MLLLERQELI DGTYEVKDLK
LEMLGETSIA HCLVYLDNGV VFIGSMLGDS QLAKLSTEPD ADGSYVQVME TFTNLGPIVD
MVVVDLERQG QGQLVTCSGA KKEGSLRIIR NGIGIHEHAT IDLAGIMGIW ALKLRKTQQE
YDDTLVLSFV GQSRRVLCTI HSRVLSLSGE EVEETEIPGF SDDQQTYYSG NVTGAQLIQV
TAASVRLVNC ETRQLVSEWK HPSAKNISVA SCNTEQVVAA VGSELYYIEI MPGELRQISQ
VTLEYEVACL DITPTVEGKS RADMVAVGLW TDISVRVLQL PKLNQLHVQM LGGEIIPRSI
LKTAFEGIHY LLCALGDGTL FYFTMDPSTG ALAECKKVTL GTQPTMLRTF KSLSTVNVFA
CSDRPTVIYS SNHKLVFSNV NLKEVNFMCP LNSQGYPDSL ALANDGSLTI GTIDEIQKLH
IRTVPLGESP RRIAYQEATQ TFGVISVRIE ISEPGTSGTV PLHPSASTTA HNVSSSVGTG
VSGSASSSAP DGITFGDEME IGSLLIIDQH TFEVTHAHQL HDNEQATSLM SCTLSDDPHT
YYCVGTAYVF PEEPEPKAGR LLLFHLSEGK LVQVAEKEVK GAVYSLVEFN GKVLAGINST
VSIFEWTADK EFRYECSYYD NILALYLKTK GDFILVGDLM RSMTLLVYLP LEGSFQEIAH
DFSPKWMTAI EILDDDTFLG AENSYNLFTC TKDSGATTDE ERYHLQDAGQ YHLGEFVNVF
RHGSLVMEHP GDASTPFQGC VLFGTVNGRI GIVAQIAQDL FNFLIQVQKK LNKVIKSVGK
IDHSLYPFPH CSNLSHSRKM EPAHGFIDGD LIESFLDLPR ARMEEVVTGL QIDDGGMKKE
CTVDDLVKTV EELTRIH
//
