ID A7S272_NEMVE Unreviewed; 231 AA.
AC A7S272;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=Homeobox domain-containing protein {ECO:0000259|PROSITE:PS50071};
GN ORFNames=NEMVEDRAFT_v1g205636 {ECO:0000313|EMBL:EDO42185.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO42185.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO42185.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR EMBL; DS469567; EDO42185.1; -; Genomic_DNA.
DR RefSeq; XP_001634248.1; XM_001634198.1.
DR AlphaFoldDB; A7S272; -.
DR STRING; 45351.A7S272; -.
DR EnsemblMetazoa; EDO42185; EDO42185; NEMVEDRAFT_v1g205636.
DR GeneID; 5514093; -.
DR KEGG; nve:5514093; -.
DR eggNOG; KOG0489; Eukaryota.
DR HOGENOM; CLU_1201087_0_0_1; -.
DR InParanoid; A7S272; -.
DR OrthoDB; 728401at2759; -.
DR PhylomeDB; A7S272; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45664:SF12; PANCREAS_DUODENUM HOMEOBOX PROTEIN 1; 1.
DR PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 97..157
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 99..158
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
SQ SEQUENCE 231 AA; 26710 MW; 7E6166A13F7F6C57 CRC64;
MNYSALFPSF DTSVTWDPSR HHLKNTENPG TLPETQGFGA GLFLDTYTSH IGRDFDGPIG
SIPVGSSNRE SLPNYLLQPI YPWMRTKKSG SRGIGGKHTK RYRTSYTNRQ LLELEKEFHY
NKYLCGTRRR ELANAMKLTE RQVKVWFQNR RMKLKKDEKQ KEDGPSAFPD YDVMKSLPRL
PRLLPTYATQ TEGYPPIEAV EHLDSQSQNA LRHYTYSNYS MLTHALNTVL Q
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