ID   A7S2F2_NEMVE            Unreviewed;       537 AA.
AC   A7S2F2;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDO42137.1};
GN   ORFNames=NEMVEDRAFT_v1g205746 {ECO:0000313|EMBL:EDO42137.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO42137.1, ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO42137.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR   EMBL; DS469568; EDO42137.1; -; Genomic_DNA.
DR   RefSeq; XP_001634200.1; XM_001634150.1.
DR   AlphaFoldDB; A7S2F2; -.
DR   EnsemblMetazoa; EDO42137; EDO42137; NEMVEDRAFT_v1g205746.
DR   eggNOG; KOG4294; Eukaryota.
DR   HOGENOM; CLU_020415_1_2_1; -.
DR   InParanoid; A7S2F2; -.
DR   OMA; ICNENAL; -.
DR   PhylomeDB; A7S2F2; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015280; F:ligand-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690:SF301; AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        40..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        467..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   537 AA;  60768 MW;  D86514E00BC15BED CRC64;
     MRRNTDPKET ALEQINQFLQ ETTAHGFGRL GATAGSKWRL YWVMFCLAAY CVFVWQLVGL
     VNQYNSKPIK TRTQLKHAQK LDFPVVTICN MNVLRASRLP PKLRTKFDQI INNTNKTSPR
     NSSNSRNAFV DPQDLSFEET KKFEILHAVT AHDDYRELVS AAHQLEDILL SCNFNGVNCR
     NSKDPTIPTY WTQTWNDNFG NCYMFNSVKT HNGEKVDLYS SSVPGESNGL TLQLNLEQNE
     YLEGITEVAG MKVTISDQGV LPFPGQQGIR IMPGQSTGIQ MTKLQTRRID PFKNRSCESS
     NEMSDKNLFF GYNMTYSIMA CKYSCLNARK IERCGCTNYN TPEMQKRNIP LCNRLNSTII
     DCLNKAYDTF EDGSCDRECP PSCSEVSFDL TVSSARWPAR SFEVTKYAYF LRVRVLNKIA
     SSSSKYFVNS ENIAQVHVYY GELDYLLVQE TLAYTFMSLL SDIGGQMGMW IGISALTCAE
     LIELVCVILA NMSNRSKKIV HINSFRPEKL GGVETIEKGG VKRIEQEVQG GVGTIEQ
//