ID   A7S364_NEMVE            Unreviewed;       392 AA.
AC   A7S364;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   RecName: Full=Caspase-3 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=NEMVEDRAFT_v1g234845 {ECO:0000313|EMBL:EDO41832.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO41832.1, ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO41832.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- SIMILARITY: Belongs to the peptidase C14A family.
CC       {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR   EMBL; DS469572; EDO41832.1; -; Genomic_DNA.
DR   RefSeq; XP_001633895.1; XM_001633845.1.
DR   AlphaFoldDB; A7S364; -.
DR   STRING; 45351.A7S364; -.
DR   EnsemblMetazoa; EDO41832; EDO41832; NEMVEDRAFT_v1g234845.
DR   GeneID; 5513609; -.
DR   KEGG; nve:5513609; -.
DR   eggNOG; KOG3573; Eukaryota.
DR   HOGENOM; CLU_036904_5_2_1; -.
DR   InParanoid; A7S364; -.
DR   OMA; PEKMFER; -.
DR   OrthoDB; 2873736at2759; -.
DR   PhylomeDB; A7S364; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0097153; F:cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd01671; CARD; 1.
DR   CDD; cd00032; CASc; 1.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR033139; Caspase_cys_AS.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   InterPro; IPR002138; Pept_C14_p10.
DR   InterPro; IPR001309; Pept_C14_p20.
DR   InterPro; IPR015917; Pept_C14A.
DR   PANTHER; PTHR10454; CASPASE; 1.
DR   PANTHER; PTHR10454:SF31; CASPASE-7; 1.
DR   Pfam; PF00619; CARD; 1.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   PIRSF; PIRSF038001; Caspase_ICE; 1.
DR   PRINTS; PR00376; IL1BCENZYME.
DR   SMART; SM00114; CARD; 1.
DR   SMART; SM00115; CASc; 1.
DR   SUPFAM; SSF52129; Caspase-like; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS01122; CASPASE_CYS; 1.
DR   PROSITE; PS50207; CASPASE_P10; 1.
DR   PROSITE; PS50208; CASPASE_P20; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT   DOMAIN          1..90
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
FT   DOMAIN          154..277
FT                   /note="Caspase family p20"
FT                   /evidence="ECO:0000259|PROSITE:PS50208"
FT   DOMAIN          293..386
FT                   /note="Caspase family p10"
FT                   /evidence="ECO:0000259|PROSITE:PS50207"
FT   REGION          86..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   392 AA;  43712 MW;  B1E106D7B3A6044E CRC64;
     MDPAHRRTLR THRLDLIKDL EADKVASTLY GVGILDETDL EDIKAAKPSQ EKAEILLDKL
     PKRGPDAFSK FCDALEDISP HLASYLRPSQ TKDSGKLSGD VEDGAAQGPI ESVDGGNAEG
     GGLTVDGGLN IFGSSSKSSS PSGDLHIYKM DKTPRGVAVI INNKDFLPAS GMHRYPRNGT
     NVDRDSLEKT FKALQFDVEV HNNKTTYETN RIIKELGQRS YSNYNAMIFA ILTHGEEGIL
     YTTDGTIEIR SMMKAFKGDN LVGKPKIFIF QACQGHEYMD GKDATDAGPE DANRVQVPVE
     ADFLYAYSTV PGYYSWRNSV NGSWFIQSIC EVFNKHMHNM DVLRMMTRVN SLVSTYQSRT
     GDYYSDRKKQ VPSIVSMLRK DLFFFPENVT QN
//