ID A7S3E5_NEMVE Unreviewed; 359 AA.
AC A7S3E5;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
GN ORFNames=NEMVEDRAFT_v1g242584 {ECO:0000313|EMBL:EDO41710.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO41710.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO41710.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR EMBL; DS469573; EDO41710.1; -; Genomic_DNA.
DR RefSeq; XP_001633773.1; XM_001633723.1.
DR AlphaFoldDB; A7S3E5; -.
DR STRING; 45351.A7S3E5; -.
DR EnsemblMetazoa; EDO41710; EDO41710; NEMVEDRAFT_v1g242584.
DR eggNOG; KOG3913; Eukaryota.
DR HOGENOM; CLU_033039_1_4_1; -.
DR InParanoid; A7S3E5; -.
DR OMA; GRVCNKM; -.
DR PhylomeDB; A7S3E5; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005109; F:frizzled binding; IBA:GO_Central.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR CDD; cd19334; Wnt_Wnt2_like; 1.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR009140; Wnt2.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027:SF37; PROTEIN WNT; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01842; WNT2PROTEIN.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..359
FT /note="Protein Wnt"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002711717"
SQ SEQUENCE 359 AA; 39846 MW; 03DE31EBC5ABB02B CRC64;
MAPAKARLGL LVLLILLYFP RKTESHWWLI SQVFALGAKV MCNSITGLIS IQRQMCLDNP
DVMVSIGKGA KLGVEECQHQ FRDQRWNCST VNGDATVFGK VMRRASRETA FVYAISSAGV
VHEVTRSCSL GELKDCSCRN KKGRSRKGFE WGGCSDNIQY GLNFAKAFVD SREVEKDARA
LMNLHNNHVG RRVVKTNMSL DCKCHGVSGS CSVRTCWKSI SSFRIVGQHL REKYTTAVQV
TVGQSGGELT NAEVSYKKPS RDDLVYLEDS PNYCMVDSNT GSLGTSGREC NGSASDTTGA
CSLLCCGRGF NTIQIEEEYK CHCKFHWCCY VKCQTCRRTT LAGSEIEKIR PSPKPCFKI
//
