ID A7S4Y1_NEMVE Unreviewed; 572 AA.
AC A7S4Y1;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=C2 domain-containing protein {ECO:0000259|PROSITE:PS50004};
GN ORFNames=NEMVEDRAFT_v1g242883 {ECO:0000313|EMBL:EDO41231.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO41231.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO41231.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
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DR EMBL; DS469580; EDO41231.1; -; Genomic_DNA.
DR RefSeq; XP_001633294.1; XM_001633244.1.
DR AlphaFoldDB; A7S4Y1; -.
DR STRING; 45351.A7S4Y1; -.
DR EnsemblMetazoa; EDO41231; EDO41231; NEMVEDRAFT_v1g242883.
DR GeneID; 5513000; -.
DR KEGG; nve:5513000; -.
DR eggNOG; KOG1028; Eukaryota.
DR HOGENOM; CLU_476772_0_0_1; -.
DR InParanoid; A7S4Y1; -.
DR OMA; CHERIGQ; -.
DR OrthoDB; 2907092at2759; -.
DR PhylomeDB; A7S4Y1; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0070382; C:exocytic vesicle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0005544; F:calcium-dependent phospholipid binding; IBA:GO_Central.
DR GO; GO:0030276; F:clathrin binding; IBA:GO_Central.
DR GO; GO:0001786; F:phosphatidylserine binding; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0048791; P:calcium ion-regulated exocytosis of neurotransmitter; IBA:GO_Central.
DR GO; GO:0071277; P:cellular response to calcium ion; IBA:GO_Central.
DR GO; GO:0017158; P:regulation of calcium ion-dependent exocytosis; IBA:GO_Central.
DR GO; GO:0014059; P:regulation of dopamine secretion; IBA:GO_Central.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR CDD; cd00276; C2B_Synaptotagmin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001565; Synaptotagmin.
DR PANTHER; PTHR10024; SYNAPTOTAGMIN; 1.
DR PANTHER; PTHR10024:SF344; SYNAPTOTAGMIN-7; 1.
DR Pfam; PF00168; C2; 2.
DR PRINTS; PR00399; SYNAPTOTAGMN.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 302..424
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 434..568
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 74..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..253
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 572 AA; 64330 MW; 3B57F8FE5CEEE7B3 CRC64;
MQTMKNNVAL VAGLATGLPV VLLVFIYVAY CCCKRKQKDE LLREPRLWRR DNRSSHDLFI
PPYMPGIVQR FVQHSSKNSS ETTSTNTSPV DDKHFFSEGS DPYRTAPDDM NGPDRDRTGS
IKALQVPAPR RSSLMQPSTS SGDSSESTYE QATPKKGVGP RSPRSLPKDS RSFEFVRPIP
VKPLITITRA ESLSKDDMNA RMESTNYDPE SSRQTYSDSQ VEARRYREGS SRSLDNIALD
RQDSERRGST DRSLALRPKS TPIRHHTQSE PTAAKIPINI SSQVIKSKRG SKGKIAHAPV
GSLGRIHVSL QYKKTTCDLF VKILQCRDLP AKDLRRNTSS PYVRIYALPS RRHNHRTNIV
TNNLNPTFNE LFIISGLTLM EVQQLALQIL VIHNEVISRN VVIGEVMVAL SGLELTGDEI
SIWRDLRPYH FQNILGELHI SVCHQPLSSR LSVTVLQARN LPKISHLNIG DPYVKVELFS
SRSRVGKKKT RVKKKTVNPK FAQTFTFDLA ADSVLDMMTM TFTVMVQDAS GCHERIGQVV
LSASSDGPEF GHWSQVIANP HCPIEQWHMI HE
//
