ID A7S571_NEMVE Unreviewed; 294 AA.
AC A7S571;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 77.
DE RecName: Full=Growth arrest-specific protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=NEMVEDRAFT_v1g185829 {ECO:0000313|EMBL:EDO41193.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO41193.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO41193.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SIMILARITY: Belongs to the GAS2 family.
CC {ECO:0000256|ARBA:ARBA00038441}.
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DR EMBL; DS469581; EDO41193.1; -; Genomic_DNA.
DR RefSeq; XP_001633256.1; XM_001633206.1.
DR AlphaFoldDB; A7S571; -.
DR STRING; 45351.A7S571; -.
DR EnsemblMetazoa; EDO41193; EDO41193; NEMVEDRAFT_v1g185829.
DR GeneID; 5512946; -.
DR KEGG; nve:5512946; -.
DR eggNOG; KOG0516; Eukaryota.
DR HOGENOM; CLU_025484_1_0_1; -.
DR InParanoid; A7S571; -.
DR OMA; DMRIERF; -.
DR OrthoDB; 1361287at2759; -.
DR PhylomeDB; A7S571; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005884; C:actin filament; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0008093; F:cytoskeletal anchor activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0051764; P:actin crosslink formation; IBA:GO_Central.
DR CDD; cd21204; CH_GAS2-like; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR PANTHER; PTHR46756:SF13; GAR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46756; TRANSGELIN; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF02187; GAS2; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00243; GAS2; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51460; GAR; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 39..162
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 193..264
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 294 AA; 33365 MW; EB16B6C7891A8CAE CRC64;
MSSGMKSDGG KQVREEKENL EPNDVDEDMR IERFGEDLNP LKEDLAEWLS RVLEVEVQAD
NFMDYLDNGV LLCKLAQLIQ KAATEWIKID KAMSVTLPSL GSRFHQNAKS GTFFARDNAA
YFLKWCKGVG IQDSVMFESD GLVLQKQPRE VLLCLLDVAR FAANFGIDPP NLVKLEKEID
EEIEQEVKPP KKEKKPAKPL AVDDEVFRLA KKYSVKIERI KEGRYIVENK INIFVRIVRN
HVMVRVGGGW DTLEHFISRH DPKKLGKILT STPAPCPNHH HGDIQCKGHC VAST
//
