ID A7S731_NEMVE Unreviewed; 512 AA.
AC A7S731;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 80.
DE RecName: Full=Ammonium transporter {ECO:0000256|RuleBase:RU362002};
GN ORFNames=NEMVEDRAFT_v1g207836 {ECO:0000313|EMBL:EDO40423.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO40423.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO40423.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593}, and CH2 x CH6
RC {ECO:0000313|EMBL:EDO40423.1};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
RN [2] {ECO:0000313|EMBL:QED21942.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=31356592; DOI=.1371/journal.pbio.3000408;
RA Andrikou C., Thiel D., Ruiz-Santiesteban J.A., Hejnol A.;
RT "Active mode of excretion across digestive tissues predates the origin of
RT excretory organs.";
RL PLoS Biol. 17:e3000408-e3000408(2019).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362002};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362002}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ammonia transporter channel (TC 1.A.11.2)
CC family. {ECO:0000256|ARBA:ARBA00005887, ECO:0000256|RuleBase:RU362002}.
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DR EMBL; DS469591; EDO40423.1; -; Genomic_DNA.
DR EMBL; MN101607; QED21942.1; -; mRNA.
DR RefSeq; XP_001632486.1; XM_001632436.1.
DR AlphaFoldDB; A7S731; -.
DR STRING; 45351.A7S731; -.
DR EnsemblMetazoa; EDO40423; EDO40423; NEMVEDRAFT_v1g207836.
DR GeneID; 5512129; -.
DR KEGG; nve:5512129; -.
DR eggNOG; KOG0682; Eukaryota.
DR HOGENOM; CLU_000445_33_1_1; -.
DR InParanoid; A7S731; -.
DR OMA; VVWVLMD; -.
DR OrthoDB; 33830at2759; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0097272; P:ammonium homeostasis; IBA:GO_Central.
DR GO; GO:0072488; P:ammonium transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.10.3430.10; Ammonium transporter AmtB like domains; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR001905; Ammonium_transpt.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR NCBIfam; TIGR00836; amt; 1.
DR PANTHER; PTHR11730; AMMONIUM TRANSPORTER; 1.
DR PANTHER; PTHR11730:SF58; AMMONIUM TRANSPORTER; 1.
DR Pfam; PF00909; Ammonium_transp; 1.
DR SUPFAM; SSF111352; Ammonium transporter; 1.
PE 2: Evidence at transcript level;
KW Ammonia transport {ECO:0000256|ARBA:ARBA00023177,
KW ECO:0000256|RuleBase:RU362002};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362002};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362002};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362002}.
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 112..131
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 178..195
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 216..239
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 251..270
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 277..300
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 306..323
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 335..353
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 373..401
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT DOMAIN 28..424
FT /note="Ammonium transporter AmtB-like"
FT /evidence="ECO:0000259|Pfam:PF00909"
FT REGION 492..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 512 AA; 55093 MW; F5131893EE283220 CRC64;
MANNTTNTTL TPPPMEYPMN LRPDDATWIL TSAFIIFTMQ SGFGLLESGM VSRKNETNIM
TKNAIDVIYG GLAYWIFGFA FSFGQPISNA FCGLSYFFAD ADESNMGMFA KYFFQLSFAT
TATTIVSGAM AERVSLKAYI LYSFLNTLSY CFPAHWVWAG DGWLARMGAI DIAGCGPVHL
VGGVSGLVAT LFLGARTGRF NAKGELVEKP MGSPTNVLLG TFMLWWGWLG FNCGSTFGIS
GGKWKLASRA AVVTINGSIG GGIFATFYSY IAHANKLMVD VFVTGILGGL VGITAICAVV
RQWESLLIGF IGGMIACVGD ALVKKLRIDD PVGCIATHGM AGIWGLLAVG LFVEVDNLEN
FSAEFGVFKG GSWHLLGIQL LVVVSIGAWA AVTNFILLYV IDKVVGLRMP LAMELDGADI
WEHGIHLQFC QYEENNAEER ESPAVSTRCH APSVMQNNPA VSTRCHAPSV MQNNFITGCI
NENVISMEDF EESKPGGVGQ VPRGASTTAL VN
//
