ID A7S9A3_NEMVE Unreviewed; 856 AA.
AC A7S9A3;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 82.
DE RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
GN ORFNames=NEMVEDRAFT_v1g109754 {ECO:0000313|EMBL:EDO39747.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO39747.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO39747.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMTC family.
CC {ECO:0000256|ARBA:ARBA00007882}.
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DR EMBL; DS469602; EDO39747.1; -; Genomic_DNA.
DR RefSeq; XP_001631810.1; XM_001631760.1.
DR AlphaFoldDB; A7S9A3; -.
DR STRING; 45351.A7S9A3; -.
DR EnsemblMetazoa; EDO39747; EDO39747; NEMVEDRAFT_v1g109754.
DR eggNOG; KOG1124; Eukaryota.
DR HOGENOM; CLU_011615_4_0_1; -.
DR InParanoid; A7S9A3; -.
DR OMA; DYTCLFC; -.
DR PhylomeDB; A7S9A3; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0000030; F:mannosyltransferase activity; IBA:GO_Central.
DR GO; GO:0035269; P:protein O-linked mannosylation; IBA:GO_Central.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR013618; TMTC_DUF1736.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44216; PROTEIN O-MANNOSYL-TRANSFERASE TMTC2; 1.
DR PANTHER; PTHR44216:SF3; PROTEIN O-MANNOSYL-TRANSFERASE TMTC2; 1.
DR Pfam; PF08409; TMTC_DUF1736; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF14559; TPR_19; 1.
DR Pfam; PF13181; TPR_8; 2.
DR SMART; SM00028; TPR; 9.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50005; TPR; 7.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 240..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 260..332
FT /note="DUF1736"
FT /evidence="ECO:0000259|Pfam:PF08409"
FT REPEAT 516..549
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 550..583
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 629..662
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 666..699
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 700..733
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 734..767
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 802..835
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 370..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 856 AA; 95586 MW; F5A3177890D6D870 CRC64;
MDSRKWSWWH TAIISSVLGI SCYLNTLDAE FVYDDSRAIL KNADLLPTTP WINLLFNDFW
GTPLTHSGSH KSYRPICIAS FRLNYAIGEL NPGGYHLVNT LLHGMVCWLT VVLSYNLVDS
HVVGVVGGLL FATHPIHTGK AVAGVVGRAD VGACLFLIAS FLCYIKSCAH PLTVGSRHTR
LRWLLGSLVL AALSMLCKEQ GVTVLGVCAV HEVVYVSKLN GKTLRSSVNK ALHRGMATRL
LSLAVTAICL IVLRMFLMGN SPPEFSPSDN PASSSESFLT RTLTFLYLPA FNFLLLLYPR
TLSFDWSMEA IPLIENVLDV RNVLTVTFYV CFISLGLYSL RRTIFEDASQ PEENGKDNNF
NSYKNGSITS KATASRNNTN GHLKKRSVSR HKDHRRSDKR TVIDETAEER PLFCFPVIVT
SLAIIVLPFV PASNVFFYVG FVVAERVLYI PSVGFCIMVG VGVGGMWSRF SNSGRRVVLV
VVGVVVVLFA AKTMQRNLDW KNEEALYRSG IDVNPAKAWG NLGNVLGNQG RTNEAEMAYR
KALSYRSNMA DTHYNLGILL AGQKRYKDAI QSYENAITFR PRLAVAHLNL GIVLDQVGRK
EDAIRILKNA STISGHGLKD PKQHSHAIAS IKYNLGRILT DLGRIEEGLT VYQDVVRTRP
AHFEPHSLYN MIGEAYTKAG LLDEAEKWYK RSLESKPSHV PAHLTLAKLY SKTGRTKQAE
ALFLKAQSLG PRDVSVWTHY GQHLYEGKQV ARAAEMFVKA SKLAPDDFDI VFNAANYLRE
SESYETAEEF YRSAVKLDQK SNIAHMNLGA ILHLLGKHQE SERYYLTALE LNPGDTMTRE
NLRKLRAIMA KKQARR
//