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Database: UniProt
Entry: A7S9A3_NEMVE
LinkDB: A7S9A3_NEMVE
Original site: A7S9A3_NEMVE 
ID   A7S9A3_NEMVE            Unreviewed;       856 AA.
AC   A7S9A3;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   24-JAN-2024, entry version 82.
DE   RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE            EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
GN   ORFNames=NEMVEDRAFT_v1g109754 {ECO:0000313|EMBL:EDO39747.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO39747.1, ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO39747.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000256|ARBA:ARBA00004922}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TMTC family.
CC       {ECO:0000256|ARBA:ARBA00007882}.
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DR   EMBL; DS469602; EDO39747.1; -; Genomic_DNA.
DR   RefSeq; XP_001631810.1; XM_001631760.1.
DR   AlphaFoldDB; A7S9A3; -.
DR   STRING; 45351.A7S9A3; -.
DR   EnsemblMetazoa; EDO39747; EDO39747; NEMVEDRAFT_v1g109754.
DR   eggNOG; KOG1124; Eukaryota.
DR   HOGENOM; CLU_011615_4_0_1; -.
DR   InParanoid; A7S9A3; -.
DR   OMA; DYTCLFC; -.
DR   PhylomeDB; A7S9A3; -.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000030; F:mannosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0035269; P:protein O-linked mannosylation; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR013618; TMTC_DUF1736.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR001440; TPR_1.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR44216; PROTEIN O-MANNOSYL-TRANSFERASE TMTC2; 1.
DR   PANTHER; PTHR44216:SF3; PROTEIN O-MANNOSYL-TRANSFERASE TMTC2; 1.
DR   Pfam; PF08409; TMTC_DUF1736; 1.
DR   Pfam; PF00515; TPR_1; 1.
DR   Pfam; PF13424; TPR_12; 1.
DR   Pfam; PF14559; TPR_19; 1.
DR   Pfam; PF13181; TPR_8; 2.
DR   SMART; SM00028; TPR; 9.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR   PROSITE; PS50005; TPR; 7.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        240..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        278..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        417..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        448..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        473..491
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          260..332
FT                   /note="DUF1736"
FT                   /evidence="ECO:0000259|Pfam:PF08409"
FT   REPEAT          516..549
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          550..583
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          629..662
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          666..699
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          700..733
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          734..767
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          802..835
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          370..401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   856 AA;  95586 MW;  F5A3177890D6D870 CRC64;
     MDSRKWSWWH TAIISSVLGI SCYLNTLDAE FVYDDSRAIL KNADLLPTTP WINLLFNDFW
     GTPLTHSGSH KSYRPICIAS FRLNYAIGEL NPGGYHLVNT LLHGMVCWLT VVLSYNLVDS
     HVVGVVGGLL FATHPIHTGK AVAGVVGRAD VGACLFLIAS FLCYIKSCAH PLTVGSRHTR
     LRWLLGSLVL AALSMLCKEQ GVTVLGVCAV HEVVYVSKLN GKTLRSSVNK ALHRGMATRL
     LSLAVTAICL IVLRMFLMGN SPPEFSPSDN PASSSESFLT RTLTFLYLPA FNFLLLLYPR
     TLSFDWSMEA IPLIENVLDV RNVLTVTFYV CFISLGLYSL RRTIFEDASQ PEENGKDNNF
     NSYKNGSITS KATASRNNTN GHLKKRSVSR HKDHRRSDKR TVIDETAEER PLFCFPVIVT
     SLAIIVLPFV PASNVFFYVG FVVAERVLYI PSVGFCIMVG VGVGGMWSRF SNSGRRVVLV
     VVGVVVVLFA AKTMQRNLDW KNEEALYRSG IDVNPAKAWG NLGNVLGNQG RTNEAEMAYR
     KALSYRSNMA DTHYNLGILL AGQKRYKDAI QSYENAITFR PRLAVAHLNL GIVLDQVGRK
     EDAIRILKNA STISGHGLKD PKQHSHAIAS IKYNLGRILT DLGRIEEGLT VYQDVVRTRP
     AHFEPHSLYN MIGEAYTKAG LLDEAEKWYK RSLESKPSHV PAHLTLAKLY SKTGRTKQAE
     ALFLKAQSLG PRDVSVWTHY GQHLYEGKQV ARAAEMFVKA SKLAPDDFDI VFNAANYLRE
     SESYETAEEF YRSAVKLDQK SNIAHMNLGA ILHLLGKHQE SERYYLTALE LNPGDTMTRE
     NLRKLRAIMA KKQARR
//
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