ID A7SAG3_NEMVE Unreviewed; 843 AA.
AC A7SAG3;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=LsmAD domain-containing protein {ECO:0000259|SMART:SM01272};
GN ORFNames=NEMVEDRAFT_v1g243962 {ECO:0000313|EMBL:EDO39304.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO39304.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO39304.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SIMILARITY: Belongs to the ataxin-2 family.
CC {ECO:0000256|ARBA:ARBA00007503}.
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DR EMBL; DS469609; EDO39304.1; -; Genomic_DNA.
DR RefSeq; XP_001631367.1; XM_001631317.1.
DR AlphaFoldDB; A7SAG3; -.
DR STRING; 45351.A7SAG3; -.
DR EnsemblMetazoa; EDO39304; EDO39304; NEMVEDRAFT_v1g243962.
DR eggNOG; KOG2375; Eukaryota.
DR HOGENOM; CLU_337805_0_0_1; -.
DR InParanoid; A7SAG3; -.
DR PhylomeDB; A7SAG3; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0010494; C:cytoplasmic stress granule; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0034063; P:stress granule assembly; IBA:GO_Central.
DR InterPro; IPR009818; Ataxin-2_C.
DR InterPro; IPR045117; ATXN2-like.
DR InterPro; IPR009604; LsmAD_domain.
DR InterPro; IPR025852; SM_dom_ATX.
DR PANTHER; PTHR12854; ATAXIN 2-RELATED; 1.
DR PANTHER; PTHR12854:SF7; ATAXIN-2 HOMOLOG; 1.
DR Pfam; PF06741; LsmAD; 1.
DR Pfam; PF07145; PAM2; 1.
DR Pfam; PF14438; SM-ATX; 1.
DR SMART; SM01272; LsmAD; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 229..296
FT /note="LsmAD"
FT /evidence="ECO:0000259|SMART:SM01272"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 807..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..455
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..830
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 91986 MW; 5625EF9A4F7B2622 CRC64;
MNQSGKRGKS RGGPNRGRRN TGSPNHQTFN QPMNDDHDFP SSYDNPCFVH AVTSLIGCHV
QLTAVNGSVY DGILRTVSPK VEVVLDVAHL VTKKIQHGSP EEYIQVPSKS ATMDTFVIAA
RNIISIDALN IDRDQVIKKD TFTDQAISNK VNGQVVHERE LKKWEDPGGG SDVHFVLGDN
QLLYNVMAVG EVNMGQRISE FIVSPAVEAQ IEHNGLDADE MLAINEQKYG VKSTYDSEML
SYTTALEKSS NQEFKEKERK AERLAREIEQ DSSFYERAEI DSGKTEEELY SAVLRTGTPS
SGQQRYVPPA RRNKQTPVMI RKDEVKTEET VASLSVSKQD EQMKPPKSDM VDDAVSSTNE
QLKPEIKSEE KEGEISLDTN PPQATPLNSM PASKNTSVSS LPGKPASQTT GSAPQAVPNP
RVIPMVSTIA ASGPGLVKPI PEHKQTDKGN REVLNDLLTF KDNFKLETKP RSPREEKKKQ
GSLSPELTES QKVEQSQDLV TQSAKQADSP KPEQKSAAIA QEASPAIKSK LNPNAKEFVL
NPNAKEFKPS PQVQRTPPLV STPQPMYAPH IPAVGSSGVV LMPYSPTTSR SMGFAGYPMV
QPSQAQMYKA PRSPGFTPGK SRFYEPSSGD PSHPPPHGHV AIPAALAAGN SIIQPGSIPS
MQYIPQGMPF MPQMVQAGSG PYMTVSQSGQ HRYIQPQSAG MTTSIAHSMH QGYQEQMTIY
ATPPHQSPAQ ASPSQQGQFF QYQAMPPQMM ANPQHPGIPH QPQGHMGAQS PSQVAPPQQF
VYLPQGMPQP GGMPASQMGQ FVPVYIAPPQ AYPRDEVDSD TQTSPTPTSE AAREEIVPQE
KDK
//
