ID A7SD79_NEMVE Unreviewed; 746 AA.
AC A7SD79;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN ORFNames=NEMVEDRAFT_v1g210465 {ECO:0000313|EMBL:EDO38317.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO38317.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO38317.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS469628; EDO38317.1; -; Genomic_DNA.
DR RefSeq; XP_001630380.1; XM_001630330.1.
DR AlphaFoldDB; A7SD79; -.
DR STRING; 45351.A7SD79; -.
DR EnsemblMetazoa; EDO38317; EDO38317; NEMVEDRAFT_v1g210465.
DR eggNOG; KOG1055; Eukaryota.
DR HOGENOM; CLU_005240_2_0_1; -.
DR InParanoid; A7SD79; -.
DR PhylomeDB; A7SD79; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IBA:GO_Central.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IBA:GO_Central.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IBA:GO_Central.
DR CDD; cd15047; 7tmC_GABA-B-like; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 3.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..746
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002714283"
FT TRANSMEM 403..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 516..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 648..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 685..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 404..710
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 746 AA; 84583 MW; 8E31EADB2CF0F96A CRC64;
MEQPLIVIAT FACALQIFAA THQKKPLYIG CMSPMTGKSA WWGRGIPVAA EIAFGLINNR
KDILPGYEFM LLANDTQVSA SATHSDLSSS KSYPYFFRTI PSLGAMRKTF LTLARRFHWT
RIAILFYNRD MQAQAARELR EELTDNNITI LSYGSYFDGD DADTQIKHLK ALDVRVVFGF
LQLTTSVICK IYRHGLYGRK YAWVINTPDN KTTWWRRTYP SLPCTEAQIY KAAEYTISLD
DMLFGMDTDQ GVSGLTTEEF QKMYTLHSQY HGLRTSLYGA LAFDAAWLMA LALNSSAQEL
GPNSSLENFH YMSESMSDVI KRNLLKIEFV GATGVVHLKS NGDRYGNFEI FQVQGNSIKL
IAKHETLSSN FTLLPGQDFV WRDGRPPLDH VTIVPQLVEF SRVGFILVCA FASCGILMSL
GFLYFNIKFR EKRFIKMSSP NLNNLIIVGC VLAYVSVVLF CVDGDKLSDL ICQVRVFTLD
IGFTLAFGAM FSKAWRVHKI TRKLRLKRRY IKDVHLVAMV MIMLSIDIII LVTWLQMDPL
TRDYKWLNRK VLLLLFGLFL VWETRKVKIT ELNDSQHIGK HGTGNWTRGF GIGELNVSQH
IEKFKQEIGL EDLGFKQMVL NTSVKIKQGI GHGNLGSENL KIHRSYNFIL TIISYFSGMA
VYNVFIVCII GVPVTMLLNE DMYEASFIIT TLCIMSCTTL TICLVFVPKV PNIPDVTGTR
YLQDDIKELG PKFFIGQKPV KPGDLD
//
