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Database: UniProt
Entry: A7SDE9_NEMVE
LinkDB: A7SDE9_NEMVE
Original site: A7SDE9_NEMVE 
ID   A7SDE9_NEMVE            Unreviewed;       299 AA.
AC   A7SDE9;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   08-MAY-2019, entry version 71.
DE   SubName: Full=Predicted protein {ECO:0000313|EMBL:EDO38248.1};
DE   Flags: Fragment;
GN   ORFNames=v1g114264 {ECO:0000313|EMBL:EDO38248.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO38248.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J.,
RA   Salamov A., Terry A., Shapiro H., Lindquist E., Kapitonov V.V.,
RA   Jurka J., Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E.,
RA   Finnerty J.R., Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   EMBL; DS469630; EDO38248.1; -; Genomic_DNA.
DR   RefSeq; XP_001630311.1; XM_001630261.1.
DR   EnsemblMetazoa; EDO38248; EDO38248; NEMVEDRAFT_v1g114264.
DR   GeneID; 5509787; -.
DR   KEGG; nve:NEMVE_v1g114264; -.
DR   eggNOG; KOG3644; Eukaryota.
DR   eggNOG; ENOG410XP43; LUCA.
DR   HOGENOM; HOG000198809; -.
DR   InParanoid; A7SDE9; -.
DR   OrthoDB; 1290238at2759; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|SAAS:SAAS00457684};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001593};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081334};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457623};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457659}.
FT   TRANSMEM    219    240       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    252    269       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    281    298       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        2    128       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      226    299       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:EDO38248.1}.
FT   NON_TER     299    299       {ECO:0000313|EMBL:EDO38248.1}.
SQ   SEQUENCE   299 AA;  34760 MW;  F9FAE167139AF898 CRC64;
     GPPVVVDLSI YVSSFGNIEE ANMEYKFFGY FRQFWKDERL ANRVNHSVIL KGDEISRMWR
     PDPFCYNARK SSLTDADADI NSMVTIHPNG DVVYSRMTII TAECELNLHK FPMDEQKCHL
     KIGSCEYLSS CSFRLLFKNV FLFKPKKGLT LLHSHSLDSY TTQDIKYRWR PPMNSSVDVR
     SRNLAQFALT SIIEVEYVEH YDLGNQNRMC VCFTFQRRLG YFLIQVYIPS IFVVVLSWIV
     FWMDKDNMGD RMALGITTVL TIMFLLGAVN ASMPRVSYPK ALDWYLMVSF TLVFLVLIE
//
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