ID A7SDL6_NEMVE Unreviewed; 94 AA.
AC A7SDL6;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=Bcl-2 Bcl-2 homology region 1-3 domain-containing protein {ECO:0000259|SMART:SM00337};
DE Flags: Fragment;
GN ORFNames=NEMVEDRAFT_v1g114394 {ECO:0000313|EMBL:EDO38185.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO38185.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO38185.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SIMILARITY: Belongs to the Bcl-2 family.
CC {ECO:0000256|ARBA:ARBA00009458}.
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DR EMBL; DS469631; EDO38185.1; -; Genomic_DNA.
DR RefSeq; XP_001630248.1; XM_001630198.1.
DR AlphaFoldDB; A7SDL6; -.
DR STRING; 45351.A7SDL6; -.
DR EnsemblMetazoa; EDO38185; EDO38185; NEMVEDRAFT_v1g114394.
DR GeneID; 5509747; -.
DR KEGG; nve:5509747; -.
DR eggNOG; KOG4728; Eukaryota.
DR HOGENOM; CLU_085401_3_1_1; -.
DR InParanoid; A7SDL6; -.
DR OrthoDB; 2909137at2759; -.
DR PhylomeDB; A7SDL6; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IBA:GO_Central.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd06845; Bcl-2_like; 1.
DR Gene3D; 1.10.437.10; Blc2-like; 1.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR046371; Bcl-2_BH1-3.
DR InterPro; IPR026298; Bcl-2_fam.
DR InterPro; IPR002475; Bcl2-like.
DR PANTHER; PTHR11256; BCL-2 RELATED; 1.
DR PANTHER; PTHR11256:SF48; BCL-2-RELATED OVARIAN KILLER PROTEIN; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR PRINTS; PR01862; BCL2FAMILY.
DR SMART; SM00337; BCL; 1.
DR SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 1..94
FT /note="Bcl-2 Bcl-2 homology region 1-3"
FT /evidence="ECO:0000259|SMART:SM00337"
FT NON_TER 94
FT /evidence="ECO:0000313|EMBL:EDO38185.1"
SQ SEQUENCE 94 AA; 10600 MW; 2961D1C4E4B837D3 CRC64;
MENAYPALYQ NISEQLNFRI NLEIVVCGMF TCVCDNILAS GITWARVVSL YAFAAALAVD
CCQTDVRIAK NISKWMGQYT KKRLSGWVRE NGGW
//
