ID   A7SE70_NEMVE            Unreviewed;       837 AA.
AC   A7SE70;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   RecName: Full=Sorting nexin-25 {ECO:0008006|Google:ProtNLM};
DE   Flags: Fragment;
GN   ORFNames=NEMVEDRAFT_v1g10501 {ECO:0000313|EMBL:EDO37987.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO37987.1, ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO37987.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS469635; EDO37987.1; -; Genomic_DNA.
DR   RefSeq; XP_001630050.1; XM_001630000.1.
DR   AlphaFoldDB; A7SE70; -.
DR   STRING; 45351.A7SE70; -.
DR   EnsemblMetazoa; EDO37987; EDO37987; NEMVEDRAFT_v1g10501.
DR   eggNOG; KOG2101; Eukaryota.
DR   HOGENOM; CLU_005899_0_0_1; -.
DR   InParanoid; A7SE70; -.
DR   OMA; LYALMGE; -.
DR   PhylomeDB; A7SE70; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR   CDD; cd06878; PX_SNX25; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037899; SNX25_PX.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775:SF48; FI21262P1; 1.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT   DOMAIN          1..165
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          289..406
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          503..636
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EDO37987.1"
FT   NON_TER         837
FT                   /evidence="ECO:0000313|EMBL:EDO37987.1"
SQ   SEQUENCE   837 AA;  97563 MW;  CD5B1B78F20B9246 CRC64;
     IDQSIQEVFD FFVRDFCLSW FRVLGKDEAA FVDLMTEELW AITSNVVERL KNVDKVNFLS
     SDLVDILTNH FQSLRLADQR NSPETAEAFV LHHCLTSKKA ELDYLRKISD VILYCFLSER
     NSQCPEMRVL LREILAYSVF QPLADMLCDP DYINQTVLIY LEAKETLTAK HKPRYAYAET
     YEDFIRMINT CNSVEELKQI RYHIIAEIMQ ATTINNLRGI EKQNQQTDNQ PLNKDAQLRT
     RNLKRYINQC TVAKAQCEKR IKLLGKPSTT PEQKPKPTNK VTGPTKMLSF AEIMDNSLAR
     SFFMSFLQNH THSRNLLSFW MAIENLRLVK PAEIVKSTHD IYQVYVAPSS DKSIMLDTSL
     VRDMEGFLNG TEGLQSFFTA QKKVYQHLEE KFYRRFVLSQ EYFMFVCQLE AEMDDLRAQQ
     KDEDNIELNW NDRVEGSNDE EKYRLNKIGQ RNNLSKYVLK DDIFVLYYQE LKKIEQEINI
     LNTERRHLEF HIERTDRWCE NIGNWNVQIE GVEWNNEDDK WIPLYVIVVH CSPINLPISP
     SGASPDRLPG ATSEGWVVTR KFNDFKILHA KLKECSSKLP NELPAPAKKW YKSLDDEFLN
     KSRLALEQYL QSLLADETLC LSEELYSFLS PSPEHLRKQT EPAKKAGFSL MAVLKRYNDI
     LSSHCHLPTI HYIWSLLSFC SSLPKDSIAE PFYALIGEVF ELKGVFRLLR RTLIAFVQIT
     FGGTINKEIQ EMLEWLVSES MIVYYIHTFR DSLWPGGQLA KTAPIRTDEE KLETKIRAMD
     HLLKDIPEVL QNLVGKKNSR LGTIKVFEAF QDVRVNKHLF YVLLEMCIFT ICPEVKS
//