ID A7SE72_NEMVE Unreviewed; 599 AA.
AC A7SE72;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN ORFNames=NEMVEDRAFT_v1g210892 {ECO:0000313|EMBL:EDO37957.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO37957.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO37957.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SIMILARITY: Belongs to the EGF domain peptide family.
CC {ECO:0000256|ARBA:ARBA00006373}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; DS469635; EDO37957.1; -; Genomic_DNA.
DR RefSeq; XP_001630020.1; XM_001629970.1.
DR AlphaFoldDB; A7SE72; -.
DR STRING; 45351.A7SE72; -.
DR EnsemblMetazoa; EDO37957; EDO37957; NEMVEDRAFT_v1g210892.
DR eggNOG; KOG1217; Eukaryota.
DR HOGENOM; CLU_455837_0_0_1; -.
DR InParanoid; A7SE72; -.
DR PhylomeDB; A7SE72; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF194; NIDOGEN (BASEMENT MEMBRANE PROTEIN); 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF14670; FXa_inhibition; 1.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..599
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002711999"
FT TRANSMEM 445..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 292..329
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 405..445
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
SQ SEQUENCE 599 AA; 65984 MW; A4B722B9AEE99567 CRC64;
MSTLIRMCFW MVVLVTSMDS SNGKKRLPIP KSLLVPGAKG IDVIDEAVEL VDEAQIFSED
HHFTKRIAIV QSAINASSNG GGLWQVDLCV FREVTQNRRK YTNLVRLQKL VRRKLGITWS
RVRHHDLRRP LYSILAARLA LETTVESFPK NVKSQARIWA QNYHKCPETS GAYTPPEEAN
KLDENTFVKV VKNSCYSGYN KCEHFCHELP QGRTACSCRK SFTLQPDGKS CKEVKASEIK
VAEEPLELNP DPRSCVVNGN QCEQSCIKVR GIVKCTCRQG FVLHNNEFSC FDMDECELSP
CDHECHNTPG SYCTCKKGYT LQTDMVTCKQ DHGNCSVNDV GCLDRCPGCP CPPGMSRQNG
HCVETDEFSL YKGVCHHNCV NTPRGYRCAC SPGYSLDENG ISCSDTDECA TGAHTCHHNC
INVPGGYFCS CAKGFRLNYD LKTCVVAYFV CMFASPARTV AYFVCMFASL ARIVAYFVCM
FASLARTVFV SYAYIYVLLR VYMTTSANAT MAVAVSDVKI SPVAIGVLAG TGLAYYPTGE
LAKMLTSALA TLVFATTTAS ISQGDTNAHA HLASGSILTG SSACLPNSRR TRDYHVIGT
//
